y. This application could substantially reduce alert fatigue and improve medication safety at the same time.

Overall, the Seegnal platform triggered 94% fewer alerts than EPIC in the inpatient setting and 93% fewer in the outpatient setting, with much higher sensitivity and specificity. see more This application could substantially reduce alert fatigue and improve medication safety at the same time.Mycobacterium Tuberculosis (TB) is an infectious bacterial disease. In 2018, about 10 million people has been diagnosed with tuberculosis (TB) worldwide. Early diagnosis of TB is necessary for effective treatment, higher survival rate, and preventing its further transmission. The gold standard for tuberculosis diagnosis is sputum culture. Nevertheless, posterior-anterior chest radiographs (CXR) is an effective central method with low cost and a relatively low radiation dose for screening TB with immediate results. TB diagnosis from CXR is a challenging task requiring high level of expertise due to the diverse presentation of the disease. Significant intra-class variation and inter-class similarity in CXR images makes TB diagnosis from CXR a more challenging task. The main aim of this study is tuberculosis recognition from CXR images for reducing the disease burden. For this purpose, a novel multi-instance classification model is proposed in this study which is based on CNNs, complex networks and stacked ensem. The experimental results show that the proposed method with AUC of 99.00 ± 0.28/98.00 ± 0.16 for MC/SZ and accuracy of 99.26 ± 0.40/99.22 ± 0.32 for MC/SZ with fivefold cross validation strategy is superior than the compared ones for diagnosis of TB from CXR images. The proposed method can be used as a computer-aided diagnosis system to reduce the manual time, effort and dependency to specialist’s expertise level.

The variability of the EPT response threshold is the most important part of accurate diagnosis of pulp status of caries-affected resorbing primary teeth. This study evaluated the mean EPT threshold values and appropriate electrode placement sites for primary molar teeth based on their physiological root resorption levels.

This study was conducted with 100 primary second molars in 100 children ages 3-12 (mean age 7.88years). Teeth were divided into 2 groups according to physiological root resorption levels. EPT response thresholds were recorded at the mesiobuccal cusp, occlusal third, middle third and cervical third of the crown. Data were analyzed according to resorption level using one-way analysis of variance and Duncan tests, with the level of significance set at 0.05.

Mean threshold values at all placement sites were higher in the group with the higher level of physiological root resorption. In terms of placement, the lowest mean EPT threshold values were obtained at the mesiobuccal cusp regardless of resorption level.

According to the study results, higher resorption levels were associated with higher physiologocial threshold values for EPT of primary second molars, with the mesiobuccal site identified as the most appropriate electrode placement site, regardless of resorption level.

According to the study results, higher resorption levels were associated with higher physiologocial threshold values for EPT of primary second molars, with the mesiobuccal site identified as the most appropriate electrode placement site, regardless of resorption level.Although there is no known difference between the clinical manifestations of SARS-CoV-2 in pregnant and non-pregnant women based on the studies published until now, in vitro fertilization (IVF) treatments were suspended during the pandemic due to uncertainties with the suggestions of associated societies. However, we do not have enough data on the exact effects of SARS-CoV-2 on fertility and pregnancy and whether there are damaging effects on IVF outcome. There is no available evidence about the transmission of SARS-CoV-2 by either sexual way or through intrauterine insemination (IUI) or IVF. Up until now, there is no report to document the presence or absence of viral RNA in follicular fluid of SARS-CoV-2-positive women. In this paper, we present a case of oocyte retrieval from a SARS-CoV-2-positive woman and the search for viral RNA by polymerase chain reaction (PCR) in the follicular fluid aspirates.Selective immunoglobulin M deficiency (SIgMD) is the isolated absence of serum immunoglobulin M (IgM) with normal levels of other serum immunoglobulins. SIgMD is associated with infections and autoimmune diseases. While there are few reports on SIgMD complicated by systemic lupus erythematosus (SLE), there are no reports on SIgMD complicated by SLE and antiphospholipid syndrome (APS); we present the first report of this kind. A 61-year-old Japanese woman presented with microscopic hematuria and proteinuria. Clinical investigations revealed an elevated serum creatinine level, an undetectable serum IgM level, and seropositivity of antinuclear antibody, anti-Smith antibody, and double-stranded DNA antibody. Radiological investigations were unremarkable. Renal biopsy revealed focal and segmental mesangial cell proliferation; thickened glomerular capillary walls; and IgG, IgA, C3, and C1q deposition, which indicated class III (A/C) lupus nephritis (Renal Pathology Society/International Society of Nephrology classification). Furthermore, anti-CLβ2GP1 antibody positivity and deep vein thrombosis were noted, which fulfilled the revised Sapporo classification criteria for the diagnosis of APS. Thus, she was diagnosed with SIgMD complicated by SLE and APS. The patient was treated with prednisolone, mycophenolate mofetil, and warfarin. After a 1-year follow-up, she achieved clinical remission of SLE and APS without infectious complications; however, the serum IgM level remained undetectable. In conclusion, SIgMD can be complicated by autoimmune disorders. Although rare, we recommend that SLE and APS be considered in patients with SIgMD who present with hematuria, proteinuria, and deep vein thrombosis. We also recommend measuring the titers of antinuclear antibodies, double-stranded DNA antibodies, and anti-CLβ2GP1 antibodies.