001). The RFS rates at 1, 3, 5, and 10 years after microwave ablation were 96.3%, 75.2%, 55.4%, and 30.4% in patients with high-PNI levels, and 94.4%, 48.8%, 36.4%, and 13.1% in patients with low-PNI levels, respectively (P<0.001). In multivariate analyses, preoperative PNI level was an independent prognostic factor for both OS and RFS.

Our results revealed the preoperative PNI level was a simple and novel predictive marker of survival and recurrence after microwave ablation in patients with early-stage HCC.

Our results revealed the preoperative PNI level was a simple and novel predictive marker of survival and recurrence after microwave ablation in patients with early-stage HCC.Sepsis is a major contributor to morbidity and mortality world-wide, with over half of the cases occurring in the pediatric population. The World Health Organization has challenged healthcare providers and organizations to improve the prevention, diagnosis, and management of sepsis.1 While the pediatric definition for sepsis was first introduced in 2005, it has not changed since that time, and does not fully represent what occurs during sepsis. The updated adult definition focuses on the dysregulation of the host response to infection leading to life-threatening organ dysfunction. Aligning with this definition, the new Pediatric Surviving Sepsis guidelines target sepsis with end-organ dysfunction and septic shock. Recommendations include utilizing automated trigger tools embedded in the electronic health record to improve timing of recognition, as well as utilization of a standardized approach to the management, and early escalation to critical care if the patient is not responding to interventions. Rapid fluid resuscitation utilizes lactated ringers rather than normal saline due to potential concerns of worse outcomes with a large chloride infusion. Selleck Bay K 8644 40-60 ml/kg is the recommended fluid goal in the first hour, watching for development of fluid overload which can also lead to increased morbidity and mortality. Broad-spectrum antibiotics should be initiated by the end of the first hour, especially in cases of septic shock. Implementation of systems capitalizing on the ability of the electronic health record to constantly screen patients, paired with rapid response teams who can assess and approach sepsis with a standardized algorithm can significantly improve the recognition and management of patients with sepsis, and save lives.11-13.

Widespread utilization of telemedicine in our practice to date has been limited to the evaluation of certain post-surgical patients. The COVID-19 pandemic acutely stressed our established system and required us to enhance our utilization of telemedicine. We hypothesized that expansion of telemedicine to new and follow up patient visits for pediatric urology could be done effectively in a way that satisfied patient and parental expectations.

Using a pre-COVID-19 established telemedicine program based in our electronic medical record (EMR), patients and providers transitioned to primarily virtual visits when clinically appropriate. Guidelines were formulated to direct patient scheduling, provider and staff education was provided, including a process map designed for multiple providers to complete video visits (VV), and the EMR was redesigned to incorporate telehealth terminology. The number of VV per provider was recorded using the electronic medical record, and patient reported outcomes (PRO) were measured enhanced use of telemedicine has proved to be an alternative method to provide care for pediatric urology patients. Families indicate a high degree of satisfaction with this technology in addition to significant time and cost savings. Telemedicine should remain a key aspect of medical care and expanded from post-operative visits to new patient and follow up visits, even as we return to our normal practices as the pandemic restrictions soften.

The EMR enabled nimble redirection of clinical care in the setting of a global pandemic. The enhanced use of telemedicine has proved to be an alternative method to provide care for pediatric urology patients. Families indicate a high degree of satisfaction with this technology in addition to significant time and cost savings. Telemedicine should remain a key aspect of medical care and expanded from post-operative visits to new patient and follow up visits, even as we return to our normal practices as the pandemic restrictions soften.There is a theoretical risk of volume overestimation if prostate AP dimension is taken on axial imaging given the anatomic obliquity of the gland on axial plane. This is analogous to slicing a salami sausage diagonally rather than perpendicularly to obtain larger slices. The most recent PI-RADS update (v2.1) now recommends obtaining the anterior-posterior measurement on sagittal imaging to mitigate the theoretical risk of the so called “salami effect” when using the ellipsoid formula for volume calculations. The authors of the recent article Comparison of PI-RADS Versions 2.0 and 2.1 for MRI-based Calculation of the Prostate Volume found the theoretical “salami effect” may not be as significant as originally thought, and perhaps slight overestimation of the AP diameter on axial measurements may yield more accurate volume estimates. Future validation studies are needed for to validate their findings. In this contemporary study, there is excellent interreader agreement among radiologist’ three dimensional measurements-confirming manual calculation can be reliably replicated in practice settings where of software-based segmentation tools are not available.Interleukin-1α (IL-1α) is an alarmin involved in the recruitment of macrophages and neutrophils during tissue inflammation. IL-1α can undergo cleavage by proteases, such as calpain-1, that enhances IL-1α binding to its receptor, although proteolytic cleavage is not necessary for biological activity. Macrophages and neutrophils are involved in the retinal inflammation associated with development of AIDS-related human cytomegalovirus (HCMV) retinitis. We therefore performed studies to test the hypothesis that IL-1α gene expression is stimulated intraocularly during retinitis development using two mouse models of murine cytomegalovirus (MCMV) retinitis that differ in method of immunosuppression, one by retrovirus-induced immunosuppression (MAIDS) and the other by corticosteroid-induced immunosuppression. MCMV-infected eyes of groups of retinitis-susceptible mice with MAIDS of 10 weeks duration (MAIDS-10 mice) and retinitis-susceptible corticosteroid-treated mice showed significant stimulation of IL-1α mRNA. Western blot analysis confirmed IL-1α protein production within the MCMV-infected eyes of MAIDS-10 mice.