To evaluate the mental health status, stressors and self-adjustment of nurses in isolation wards at different periods in Wuhan, China.

Mental health issues easily occurred among the frontline medical workers of a major epidemic. However, the stressors and psychological adjustments experienced by nurses have not been well described. selleck chemicals llc This is crucial to improving clinical quality and nursing safety and ensuring nurses’ physical and psychological health.

We performed a cross-sectional prospective study using the Self Reporting Questionnaire-20, stressor and self-adjustment questionnaire administered to frontline nurses in Wuhan at two time points after they had worked in isolation wards for 7-10days (T

) and 2months (T

). This paper complies with the STROBE reporting guideline for cross-sectional studies.

T

has 92 respondents, and T

has 86. The positive rates of mental health problems were 26.09% and 9.30%, respectively, showing significantly different in the two periods. The main factors influencstment status among nurses working Wuhan during the outbreak of COVID-19, to provide administrators with a scientific basis to effectively intervene.

To outline the development and effect of an audit with feedback implementation strategy that intended to increase the rate of voluntary medication error reporting by nurses.

Medication errors are a serious global health issue. Audit with feedback is a widely used implementation strategy that has potential to modify nurses’ reporting behaviour and improve medication error reporting rates.

Quasi-experimental implementation study (fulfilling the TIDieR checklist) with two pairs of matched wards at a private hospital in Australia was conducted from March 2015-September 2016. One ward from each pair was randomised to either the intervention or control group.

Nurses within intervention wards received audit with feedback on a quarterly basis over a 12-month implementation period. Control wards underwent quarterly audits only (without feedback). Feedback consisted of a one-page infographic poster, with content based on medication error data obtained from audits and the hospitals’ risk management system (RiskMlack of intervention effects, the use of a published checklist to optimise the reporting quality of this study will contribute to the field by furthering the understanding of how to enhance audit with feedback implementation strategies for nurses.

To investigate the morphological and molecular characteristics of Leydig cell tumours (LCTs) of the testis for the identification of cases that may metastasise.

Six parameters for a predictive model of the metastatic risk were evaluated in 37 benign and 14 malignant LCTs of the testis [LCT Scaled Score (LeSS)]. The tumour size (benign LCTs, mean 13.3mm; malignant LCTs, mean 44mm) (P<0.001) and five other parameters (infiltrative margins, necrosis, vascular invasion, mitotic count, and nuclear atypia) showed significant differences (Wilcoxon’s test, P<0.001). Eight metastatic LCTs and one benign LCT had infiltrative margins. Foci of coagulative necrosis occurred in 10 metastatic LCTs, whereas vascular invasion was identified in nine of 14 metastatic LCTs and none of 37 benign LCTs. Benign LCTs showed <2 mitoses/10 high-power fields (HPFs), whereas a high mitotic count (range, 3-50 mitoses/10 HPFs) was a feature of malignant LCTs. These parameters were selected by use of an inferential analysis based on univariate logistic regression models to develop a score. A LeSS of <4 correctly identified all histologically and clinically benign LCTs. A LeSS of ≥4 correctly identified all malignant LCTs. MDM2 and CDK4 immunostains were applied in all 51 cases benign LCTs were negative; three of 11 malignant LCTs (27%) showed strong and diffuse immunopositivity and high levels of MDM2 and CDK4 amplification as determined with fluorescence in-situ hybridisation analysis and next-generation sequencing.

We provide a new tool, the LeSS, for the prediction of malignant behaviour in LCTs.

We provide a new tool, the LeSS, for the prediction of malignant behaviour in LCTs.Strength and balance training are now recommended in many physical activity (PA) guidelines. However, it is unclear whether these recommendations are applicable to middle-aged adults. We aimed to examine the associations of sitting and physical activity times with grip strength and standing balance performance in mid-life. Up to 4726 participants from the 1970 British Cohort study, with data on sitting and activity (measured using a thigh-worn accelerometer (activPAL3-micro)), grip strength and balance times at age 46 years were included in analyses. Associations of sitting, moderate-vigorous, and total PA times with grip strength and balance performance were tested using linear and multinomial logistic regression models, respectively. Greater time spent sitting was associated with weaker grip strength even after adjustment for potential confounders and MVPA time (fully adjusted regression coefficient -0.51 kg (95% CI -0.63, -0.39) per 1-hour sitting/day). Associations of PA time with grip strength were not independent of sitting time. There was only a weak association between sitting time and balance performance but greater MVPA and total PA times were associated with higher relative risks of successfully balancing for 30 seconds with eyes closed (vs poor balance). However, these associations were fully attenuated after adjustments for covariates. In summary, among a sample of middle-aged adults a robust association between sitting time and grip strength was observed. These findings suggest potential benefits of actively promoting less sitting alongside activities that specifically benefit muscle strength and balance performance in mid-life to ensure that people maintain all important aspects of their physical capability as they age.Focal dystonia, by definition, affects a specific body part; however, it may have a widespread neural substrate. We tested this hypothesis by examining the intrinsic behaviour and the neuronal properties that are modulated by changes in the physiological behaviour of their connections, that is feedback dependence, of the isolated pallidal neurons. During deep brain stimulation surgery in 12 patients with isolated cervical dystonia (without hand involvement), we measured spontaneous as well as evoked single-unit properties in response to fist making (hand movement) or shoulder shrug (neck movements). We measured the activity of isolated neurons that were only sensitive to the neck movements, hand movement, or not responsive to hand or neck movements. The spontaneous firing behaviour, such as the instantaneous firing rate and its regularity, was comparable in all three types of neurons. The neck movement-sensitive neurons had prominent bursting behaviour in comparison with the hand neurons. The feedback dependence of the neck movement-sensitive neurons was also significantly impaired when compared to hand movement-sensitive neurons.