e. 2mL) is able to predict performance at larger scale (i.e. 2 L bioreactor, two orders of magnitude scale-up). Moreover, the results highlight the ability of the optimized process to ensure high titer of glutathione using a low-cost carbon source.

From the obtained results, it could be observed that the model established from small scale culture (i.e. 2 mL) is able to predict performance at larger scale (i.e. 2 L bioreactor, two orders of magnitude scale-up). Moreover, the results highlight the ability of the optimized process to ensure high titer of glutathione using a low-cost carbon source.The illusory truth effect occurs when the repetition of a claim increases its perceived truth. Previous studies have demonstrated the illusory truth effect with true and false news headlines. The present study examined the effects that different ratings made during initial exposure have on the illusory truth effect with news headlines. In two experiments, participants (total N = 575) rated a set of news headlines in one of two conditions. Some participants rated how interesting they were, and others rated how truthful they were. Participants later rated the perceived accuracy of a larger set of headlines that included previously rated and new headlines. In both experiments, prior exposure increased perceived accuracy for participants who made initial interest ratings, but not for participants who made initial truthfulness ratings. The increase in perceived accuracy that accompanies repeated exposure was attenuated when participants considered the accuracy of the headlines at initial exposure. Experiment 2 also found evidence for a political bias participants rated politically concordant headlines as more accurate than politically discordant headlines. The magnitude of this bias was related to performance on a cognitive reflection test; more analytic participants demonstrated greater political bias. These results highlight challenges that fake news presents and suggest that initially encoding headlines’ perceived truth can serve to combat the illusion that a familiar headline is a truthful one.BCL2 apoptosis regulator (BCL2) is a cause of tumorigenesis whose CA-repeat promoter polymorphisms has inconsistent association with various types of cancers. The association of BCL2 polymorphism with breast cancer was investigated in the Isfahan province of Iran. PCRamplification of the CA-repeat was followed by polyacrylamide gel electrophoresis and direct sequencing for 120 breast cancer women and an equal number of corresponding healthy control individuals. Seven different alleles, ranging from 11 to 17 CA-repeats were observed. Short alleles with 11 to 14 repeats were protective (OR 0.363, P = 0.001), but large alleles with 15 to 17 repeats were threatening against breast cancer development (OR 2.780, P = 0.001). Accordingly, genotypes with large alleles showed a higher risk of breast cancer development (OR 3.400, P = 0.004). ERS1\ERBB2 positive breast cancer patients, but not PGRpositive ones, showed protection against breast cancer (OR 0.405, OR 0.346 respectively). In conclusion, women with at least one large allele of BCL2 were 3.4 times at higher risk of breast cancer development in the Isfahan province of Iran.Birds have been historically affected by metals and are considered powerful sentinels of environmental pollution. Some toxic elements (Pb, Cd, Hg, As) have been broadly studied in avian species and are well known for their accumulation capacity and deleterious effects, including alterations in vitamin levels. Vitamins A, E and D3 are fat-soluble nutrients involved in multiple physiological functions (e.g., immune function, vision, reproduction, growth and development). Publications reporting metal-induced effects on vitamins in birds are growing and, in some cases, results seem contradictory, making them difficult to interpret. Therefore, a clear view of the overall picture is needed. LEE011 This mini-review article aims to compile relevant data and describe current knowledge on the effects of the most toxic elements (i.e., Pb, Cd, Hg, As) on vitamins A, E and D3 in birds. Although vitamins are diet dependent, they are strongly regulated and transformed in the organism, and metal-related disruption in their homeostasis may provoke alterations in different directions. Moreover, vitamin status and form in vivo is the result of complex interacting processes in the organism and metal exposure may produce cascade effects. Different factors that may contribute to the variable response of vitamins to metals in birds are discussed. Some final remarks and recommendations are provided for future studies. This mini-review shows an overview of the current knowledge in metal-induced alterations in vitamins of special concern for avian ecotoxicology, a research discipline facing important challenges in the coming years.Enzootic nasal tumor virus type 1 (ENTV-1) (ovine nasal tumor virus) and ENTV-2 (caprine nasal tumor virus) are known to be causative agents of enzootic nasal adenocarcinoma (ENA) in sheep and goats, respectively. Although the nucleotide and amino acid sequences of ENTV-1 and ENTV-2 are quite similar, they are recognized as phylogenetically distinct viruses. The envelope protein of ENTV-1 functions as an oncoprotein in the in vitro transformation of epithelial cells and fibroblasts. Thus, it is the primary determinant of in vivo tumorigenesis in ENA. As per our knowledge, no previous studies have reported in detail the role of ENTV-2 in ENA tumorigenesis. Here, in order to investigate the molecular mechanism of caprine ENA oncogenesis by ENTV-2, we have attempted to identify the transforming potential of ENTV-2 envelope, and investigated the activation of cell signaling pathways in oncogenic transformation. Our findings confirmed that ENTV-2 envelope was capable of inducing oncogenic transformation of rat cell lines in vitro. Further, we found that MAPK, Akt, and p38 were constitutively activated in ENTV-2 envelope-transformed clone cells. In addition, inhibitor experiments revealed that MEK-MAPK and PI3K-Akt signaling pathways are involved in the ENTV-2 envelope-induced cell transformation. These data indicate that ENTV-2 envelope could induce oncogenic transformation by signaling pathways that are also utilized by ENTV-1 envelope.