Interestingly, apremilast could dose-dependently inhibit the activation of M1 and T cells in vitro through promoting the phosphorylation of CREB. In summary, our research suggested that inhibiting PDE4 by apremilast might provide a novel therapeutic option for clinical treatment of SSc patients.Mantle cell lymphoma (MCL) is a lymphoproliferative…[Read more]

Current cloud computing causes serious restrictions to safeguarding users’ data privacy. Since users’ sensitive data is submitted in unencrypted forms to remote machines possessed and operated by untrusted service providers, users’ sensitive data may be leaked by service providers. Program obfuscation shows the unique advantages that it can…[Read more]