In the sample set, a positive correlation between HNF1B and ECI2 protein expression was detected (P=0.005). HNF1B mRNA was also positively correlated with HNF1B protein expression (P=0.001). HNF1B promoter methylation was detected in 26/67 (38.8%) of cases. A novel pathogenic somatic HNF1B mutation was detected in 1/61 (1.6%) of the analysed HGSC…[Read more]

ding on the growth media. The results allow flexible construction of Rhodococcus strains using the studied promoters, and demonstrate a valuable approach for complex characterization of promoters intended for biotechnological strain construction.The field of nanomedicine continues to grow with new technologies and formulations in development for…[Read more]

Patients with chronic lymphocytic leukemia (CLL) treated with Ibrutinib often present hemorrhagic complications. Platelets dysfunction is well documented by aggregometry and flow cytometry, but the mechanisms by which Ibrutinib treatment influences the platelets status is yet to be evaluated. The aim of this study is to identify platelet membrane…[Read more]

With the undergoing world outbreak of Fusarium wilt of bananas, it is essential to unravel all the possible process of dissemination of this disease. The host-pest interactions of the banana weevil with banana plants make this insect an important potential vector. This study, carried out in controlled conditions, explores the interaction between…[Read more]