Mechanistically, we demonstrated that TRIM21, via facilitating the ANXA2 trafficking at the PM, enabled to release the transcription factor EB (TFEB, a master regulator of autophagy) from the ANXA2-TFEB complex, which in turn entered into the nucleus for the regulation of OS cell autophagy. In accord with previous findings that autophagy plays a…[Read more]

AbstractIn the ophioplutei of brittle stars, the posterior coeloms are commonly assumed to be produced by a transverse fission of the initially formed coeloms; but in ophioplutei of Ophiopholis aculeata, the posterior coeloms first appear separately as aggregations of mesenchyme-like cells near the base of the posterolateral arms. Initiation of…[Read more]

Objective To investigate the clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor(LPF-NT). Methods Three cases of LPF-NT in Children’s Hospital of Fudan University from December 2018 to December 2019 were analyzed for their diagnosis and differential diagnosis. Results One case was male and two cases were…[Read more]

Objective To investigate the clinicopathological and molecular genetic features of lipofibromatosis-like neural tumor(LPF-NT). Methods Three cases of LPF-NT in Children’s Hospital of Fudan University from December 2018 to December 2019 were analyzed for their diagnosis and differential diagnosis. Results One case was male and two cases were…[Read more]

Vertebral fractures (VFx) are common among older adults. Epidemiological studies report high occurrence of VFx at mid-thoracic and thoracolumbar regions of the spine; however, reasons for this observation remain poorly understood. Prior reports of high ratios of spinal loading to vertebral strength in the thoracolumbar region suggest a possible…[Read more]

Qualitative research may clarify reasons why partner effects in the model were found to be non-significant. Further research should re-test this model with a larger sample size during childhood, when parents provide significant behavioral models for their children-as well as in adolescence, considering the peer group-to develop guidelines for…[Read more]

Placentitis was also associated with aberrant expression of several placenta-regulatory genes, such as PLAC8, PAPPA, LGALS1, ABCG2, GCM1, and TEPP, which could negatively affect placental functions. In conclusion, our findings revealed for the first time the key regulators and mechanisms underlying placental inflammation, separation, and…[Read more]

properly incentivize and support the use of this data for improving PC communication.

Assessing provider communication at the point-of-care is acceptable and useful to clinicians. check details Challenges remain to properly incentivize and support the use of this data for improving PC communication.

Phone calls as part of multimodal fecal…[Read more]