At 4 °C, the highest (p less then 0.05) TAC (peel) was observed after 14 days of storage (1.2-fold increase). TPC showed similar results. The highest (p less then 0.05) TPC was recorded in the peel after 10 days of storage at 23 °C (2.3-fold increase) and after 14 days of storage at 4 °C (1.3-fold increase), respectively. Total carotenoids in th…[Read more]

gs of our study, silencing of miR-21a-5p by synthetic antagomiR could constitute a novel therapeutic approach in myocarditis. Hence, research on this matter certainly warrants further scientific attention and investigation.Predictive toxicology is increasingly reliant on innovative computational methods to address pressing questions in chemicals…[Read more]

Futhermore, after each functionalization step, the nanomaterial surface charge drastically changed, with critical impact on RBC lysis and corona formation. While IONCs@SiO2 and IONCs@SiO2-TTA-Eu-DBM showed hemolytic properties in a dose-dependent manner, the IONCs@SiO2TTA-Eu did not present any hemolytic effect up to 300 μg mL-1. Protein corona…[Read more]

This study reports a global DNA hypermethylation in tumors of recurrent ccRCC patients. Furthermore, DMCpGs were capable of discriminating between aggressive and less aggressive tumors, in addition to SSIGN score. Therefore, DNA methylation presents itself as a potentially strong biomarker to further improve prognostic power in patients with low…[Read more]

k factors and postoperative outcomes. These data enable surgeons and policy-makers to reduce cost variation, improve quality through standardization, and ultimately provide greater value to patients.

Since isolated congenital mitral regurgitation (ICMR) is rare, the role of artificial rings in annuloplasty for ICMR is still debated. This study…[Read more]

Coronavirus disease 2019 (COVID-19) has placed a great burden on critical care services worldwide. Data regarding critically ill COVID-19 patients and their demand of critical care services outside of initial COVID-19 epicenters are lacking. This study described clinical characteristics and outcomes of critically ill COVID-19 patients and the…[Read more]

The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes. Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis. Compensatory mechanisms to regulate the intracellular bile acid concentration in human hepatocytes with BSEP deficiency remain unclear. To define…[Read more]

In terms of discriminative validity, the sample of individuals with SAD had higher SBSA total and subscale scores compared with a sample of individuals without SAD (N = 32). These findings provide a psychometric evidence base justifying the use of the SBSA for the assessment of maladaptive social-evaluative beliefs.Continuous monitoring of…[Read more]

Altered subcellular localizations of EC-typic claudin-5, vascular endothelial cadherin and von Willebrand factor were also observed. Taken together, all experiments with (retinal) EC cultivated in common DMEM need to be interpreted very cautiously and should at least include phenotypic validation.

Intrauterine contraceptive device (IUCD)…[Read more]