The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, due to close similarity with the natural receptor, hold out the promise of being broadly active against virus variants without…[Read more]

The discharge of household sewage and wastewater from urban areas was a major source of river FC pollution, particularly for low and medium pollution levels, while farmland land use was negatively correlated with the medium and high levels of river FC pollution in the highly urbanized watershed. Biochemical oxygen demand and suspended solids were…[Read more]

Type I and III leukocyte adhesion deficiencies (LADs) are primary immunodeficiency disorders resulting in early death due to infections and additional bleeding tendency in LAD-III. The curative treatment of LAD-I and LAD-III is allogeneic hematopoietic stem cell transplantation (allo-HSCT). In this retrospective multicenter study, data were…[Read more]

Background. In low-income countries, pediatric emergency care is largely underdeveloped although child mortality in emergency care is more than twice that of adults, and mortality after discharge is high. Daratumumab Aim. We aimed at describing characteristics, triage categories, and post-discharge mortality in a pediatric emergency population in…[Read more]