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  • Herrera Lee posted an update 8 days ago

    Our study indicates that CTR-female rats are able to show third party prosocial behavior in response to witnessing aggressive encounters between conspecifics in a seminatural environment. In addition, we showed that perinatal FLX exposure impairs the display of prosocial behavior in female rats. Moreover, we found no signs of prosocial behavior in CTR- and FLX-males after natural aggressive encounters. After white-noise exposure the effects in third party prosocial behavior of CTR-females ceased to exist. We conclude that female rats are able to show prosocial behavior, possibly in the form of consolation behavior. In addition, the negative effects of perinatal fluoxetine exposure on prosocial behavior could provide additional evidence that SSRI treatment during pregnancy could contribute to the risk for social impairments in the offspring. In one human predictive learning experiment, we demonstrated that an individual’s propensity for response recovery following discrimination reversal learning is stable over time. Participants received four sessions of training with the first three sessions being separated by one week each, while the last session was conducted after a delay of four weeks. During each session, participants initially received discrimination training (E+, F-) in one context, followed by discrimination reversal training (E-, F+) in another context. Sessions each completed with a test, in which the stimuli were presented in the context of initial acquisition. Each test revealed response recovery according to the initially acquired stimulus-outcome contingencies. Furthermore, the strength of response recovery was correlated across sessions that were separated by one week (Sessions 1 and 2), and across sessions separated by four weeks (Sessions 3 and 4). Overall, intra-individual test behavior was stable in 87 % of participants across two sessions, and in 79 % of participants across four sessions. Our results indicate that inter-individual differences in response recovery are a reliable phenomenon, which is a finding that is not accounted by current theories of context-dependent learning. ZBTB7A is a member of the POK family of transcription factors that possesses a POZ-domain at the N-terminus and Krüppel-like zinc-finger at the c-terminus. ZBTB7A was initially isolated as a protein that binds to the inducer of the short transcript of HIV-1 virus TAT gene promoter. The protein forms a homodimer through protein-protein interaction via the N-terminus POZ-domains. ZBTB7A typically binds to the DNA elements through its zinc-finger domains and represses transcription both by modification of the chromatin organization and through the direct recruitment of transcription factors to gene regulatory regions. ZBTB7A is involved in several fundamental biological processes including cell proliferation, differentiation, and development. It also participates in hematopoiesis, adipogenesis, chondrogenesis, cellular metabolism and alternative splicing of BCLXL, DNA repair, development of oligodendrocytes, osteoclast and unfolded protein response. Aberrant ZBTB7A expression promotes oncogenic transformation and tumor progression, but also maintains a tumor suppressive role depending on the type and genetic context of cancer. In this comprehensive review we provide information about the structure, function, targets, and regulators of ZBTB7A and its role as an oncogenic driver and transcriptional repressor in various human diseases. OBJECTIVE To report the initial case of robotic-assisted level IV inferior vena cava (IVC) tumor thrombectomy, with the supra-and infradiaphragmatic caval segments managed purely by a robotic-assisted technique. METHODS A 67-year-old female presented with an 5.3 × 2.4 cm right renal tumor and a level IV IVC tumor thrombus, 16.5 cm in length, extending 1.5 cm into the right atrium. Through a robotic trans-abdominal approach, the infrarenal and retrohepatic IVC, left renal vein and right kidney were secured. Using a robotic transthoracic approach, the thrombus was milked out of the right atrium. The intrapericardial caval segment was secured and the right atrium was excluded. No cardiopulmonary bypass was used. A cavotomy was made at the right renal vein os and the tumor thrombus was extracted en-bloc in a retrograde manner under transesophageal echocardiographic visualization. RESULTS Total operative time was 211 minutes, including robotic docking, with 90 minutes spent on taking down intraabdominal adhesions. Caval clamp time was 13 minutes. Estimated blood loss was 100 mL. Postoperatively, the patient developed atrial fibrillation with RVR requiring diltiazem infusion (Clavien Grade II). Hospital stay was five days. There were no further complications. Pathology revealed an Angiomyolipoma and negative surgical margins. CONCLUSIONS This is the initial report of a purely robotic-assisted level IV inferior vena cava tumor thrombectomy,for an angiomyolipoma with tumor thrombus extending 1.5 cm into the right atrium, Both the supra-and infradiaphragmatic caval segments were managed robotically. This report further extends the field of robotic surgery. We present a case of an eroded mesh mid-urethral sling into a urethral diverticulum. Preoperative MRI and 3-dimensional translabial ultrasound aided in the identification and surgical approach. Vaginal excision of sling with urethral diverticulectomy and complex urethral reconstruction was performed. To the author’s knowledge, this is the first case documented in the literature describing an eroded mesh mid-urethral sling into a urethral diverticulum. Penile calciphylaxis is a difficult urologic condition to manage. Sodium succinate order First described by Wood et. al in 1997, penile calciphylaxis is a rare cause of penile gangrene.1 One study found the overall mortality rate associated with peile calciphylaxis to be 64%, with a mean time to death of 2.5 months.2 Additionally, no statistically significant difference in survival has been seen between patients treated with penectomy and those treated nonoperatively.3 We report a case of penile calciphylaxis in a patient treated with partial penectomy with scrotoplasty who has survived greater than one year without any complication or progression of disease.

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