This Open Question article highlights current advances in the study of non-apoptotic roles of apoptotic proteins. Apoptosis is a highly regulated and energy-requiring process in which cells actively kill themselves. Apoptosis helps remove extra cells to sculpt organs during embryo development and culls damaged cells throughout the body. Apoptosis…[Read more]

05). TNC patients (17/23) more often than PFIC patients (20/42, P=.041) harboured biallelic non-null variants (predicted not to terminate translation prematurely). TNC patient livers (7/7) more often than PFIC patient livers (5/16, P=.005) expressed immunohistochemically detectable BSEP. Kaplan-Meier analysis showed better prognosis for patients…[Read more]