t suitable for clinical application in individual patients. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES The mechanisms of attrition of the Fontan population have been poorly characterised and it is unclear whether some of the deaths are potentially preventable. We analysed…[Read more]

OBJECTIVES To assess the potential impact of using screening recommendations for bleeding disorders in patients with Noonan syndrome on perioperative bleeding complications. STUDY DESIGN We performed a retrospective, single-site cohort study; patients were identified by query of the electronic medical record. All patients with a clinical diagnosis…[Read more]

Super elongation complex (SEC) is a positive regulator of RNA polymerase II, which is required for HIV-1 proviral transcription. AFF1/4 is the scaffold protein that recruits other components of SEC and forms dimer depending on its THD domain (TPRL with Handle Region Dimerization Domain). Here we report the crystal structure of the human AFF4-THD…[Read more]

857 was obtained via similarity-based hierarchical clustering using 18 DEGs between stages I and II, and 11 DEGs between stages III and IV, identified through Wilcoxon rank sum test and quantile approach. Additionally, we offer this classification process as an R function. This is the first report of a model distinguishing the pathological tumour…[Read more]

Surgical (879 ± 175 minutes vs 684 ± 257 minutes) and CPB times (376 ± 124 minutes vs 234 ± 122 minutes) were longer in patients who received FEIBA than those who did not. Although the indexed volume of packed red blood cells (128.4 ± 82.2 mL/kg) and fresh frozen plasma (64.2 ± 41.1 mL/kg) was similar in patients who did and did not receive FEIBA…[Read more]

95 respectively. The non-focus area of the first CT image of COVID-19 pneumonia has obvious difference in different clinical types. The AUTO-ML classification model of Radiomics based on this difference can be used to predict the clinical types of COVID-19 pneumonia.Therapeutic failure in prostate cancer (PC) is believed to result from its…[Read more]

The mean relative abundances of important enzymatic proteins (aminopeptidase and calcium-transporting ATPase) were higher in control groups, whereas mean relative abundances of oxysterol-binding protein and fatty acid-binding protein were higher in higher dietary sterol groups.Aflatoxins (AFs) are secondary metabolites produced by plant fungal…[Read more]

motions are related to the rumors spread online in the context of COVID-19 in China. Moreover, these findings provide several suggestions, such as the use of web-based monitoring methods, for relevant authorities and policy makers to guide public emotions and behavior during this public health emergency.This article addresses the quantitative…[Read more]

Moreover, the investigation of aneuploidies in senesced hAFCs demonstrated the rate of total chromosomal abnormalities as 4.3% and 9.9% in AmnioMAX- and DMEM-cultured hAFCs, respectively.

hAFCs showed a low rate of CIN in two AmnioMAX II and DMEM mediums and also in the proliferative and senescent phases. Therefore, they could be…[Read more]

The fundamental mechanism underlying negative-ion catalysis involves bond-strength breaking in the transition state (TS). Doubly-charged atomic/molecular anions are proposed as novel dynamic tunable catalysts, as demonstrated in water oxidation into peroxide. Density Functional Theory TS calculations have found a tunable energy activation barrier…[Read more]

Lewis acidity plays a key role in the catalytic activity of lead ion (PbII) in the hydrolysis of glucose in solution under harsh synthetic conditions. We report a number of structurally similar d-gluconamide amphiphiles as functional organic ligands with active an -NH center capable of coordinating PbII (viz., PbII-N-C) in basic condition to…[Read more]