com/0x462e41/SS3D/.Among noble gases, Helium and Neon have smaller size, high ionization potential and low polarizability due to which these two gases exhibit weak binding affinities toward any surface. EED226 chemical structure Bartlet’s discovery and subsequent similar successful discoveries of stable complexes of noble gases opened new avenues for the storage of noble gases particularly on the new surfaces and their interactions for the storage of these gases. Here, we report the adsorption of light noble gases on polycationic clusters. Our current work not only investigates the interaction behavior of He and Ne with (Sb7Te8)5+ cluster but also explores the saturation limit of the cluster for He and Ne. Stability of various complexes of He and Ne with cationic surfaces is determined by the calculation of their interaction energies which reveal that the adsorption of single and multiple atoms of noble gases at faces of double cubic cluster is comparatively more favorable than at the bond lengths. Electronic properties such as HOMO-LUMO gaps show that complexes of He and Ne are more stable electronically than that of pure cluster, because HOMO-LUMO gap of complexes are higher than the bare polycationic cluster. NCI analysis of iso-surfaces and RDG maps confirms the presence of van der Waals forces between light noble gases and polycationic clusters. Saturation studies reveal that cluster can adsorb eleven He and/or ten Ne atoms with no or minimum distortion in the geometry of cluster. The results showed that Ne has greater tendency to interact with polycationic clusters due to the large electronic cloud and polarizability value than He.The geometries, electronic properties, and chemical bonding of (VH2)n (n=10-30) nanoclusters are systematically investigated by a combination of artificial bee colony optimization with density functional theory calculations. Structure analysis indicates that the structures of (VH2)n nanoclusters tend to be a disorder, where the hydrogen atoms prefer to occupy the hollow sites among different V atoms, binding three V atoms to form the HV3 moieties. The bond length suggests that the average V-V bond lengths are about 2.60 Å, and the average V-H bond lengths are near 1.86 Å, which close to the experimental values of 2.77 Å and 1.79 Å for the V-V and V-H of bulk vanadium hydride, respectively. Interestingly, the coordination numbers of V-H fluctuate around 5.50 in the nanoclusters, and the corresponding value of H-V is estimated at 3.00. Moreover, the electronic properties and chemical bonding analyses indicate that d orbitals of V atoms and s orbitals of H atoms have a relatively large overlap to form sigma bonds. Specifically, the σ molecular orbital of H2 can donate electronic density to the d orbital of V atom, exhibiting the Kubas interaction in V24H48 and V29H58 nanoclusters. Kubas interaction results in a longer bond between the hydrogen molecule and the V atom.

Shift work may cause insomnia and sleepiness in individuals. The present study aimed to exam shift work disorder (SWD), and to investigate their associations with individual characteristics.

A total of 1833 shift workers were assessed using the Pittsburg Sleep Quality Index, Epworth Sleepiness Scale (ESS), Composite Scale of Morningness (CSM), Circadian Type Inventory (CTI), Center for Epidemiologic Studies-Depression Scale (CES-D), Beck Anxiety Inventory (BAI) and other self-compiled socio-demographic questionnaires.

In the current sample, 17.1% shift workers have experienced insomnia symptoms, 20.9% were tested for daytime sleepiness, and 19.9% were categorized as having SWD. Logistics regressions revealed that history of mental disorders (OR=2.04, 95% CI=1.30-3.21), chronic physical illness (OR=1.53, 95% CI=1.17-1.99), CES-D scores (OR=1.03, 95% CI=1.02-1.05), BAI scores (OR=1.04, 95% CI=1.03-1.06), languid/vigorous tendencies (OR=1.06, 95% CI=1.03-1.10) were positively associated with the onset of SWD, while morningness (OR=0.97, 95% CI=0.94-0.99) decreased the odds of SWD onset.

These findings suggested that attention should be drawn to individuals with mental and chronic diseases in when scheduling work shifts. While SWD and its associates should be considered when providing psychological services to shift workers.

These findings suggested that attention should be drawn to individuals with mental and chronic diseases in when scheduling work shifts. While SWD and its associates should be considered when providing psychological services to shift workers.Histone deacetylase 8 (HDAC8) has emerged as a promising drug target for cancer therapeutics development. HDAC8 has been reported to regulate cancer cell proliferation, invasion and promote metastasis through modulation of cell cycle associated proteins. Of late, phytocompounds have been demonstrated to exhibit anticancer and anti-HDAC8 activity. Here, we have shown the HDAC8 inhibitory potential of an active phytocompound from HC9 (herbal composition-9), a polyherbal anticancer formulation based on the traditional Ayurvedic drug, Stanya Shodhan Kashaya. HC9 was recently reported to exhibit anticancer activity against breast cancer cells through induction of cell cycle arrest, decrease in migration and invasion as well as regulation of inflammation and chromatin modulators. In silico studies such as molecular docking, molecular dynamics (MD) simulation and binding free energy analyses showed greater binding energy values and interaction stability of MA with HDAC8 compared to other phytocompounds of HC9. Interestingly, in vitro validation confirmed the anti-HDAC8 activity of MA. Further, in vitro studies showed that MA significantly decreased the viability of breast and prostate cancer cell lines, thereby confirming its anticancer potential.

Proprioceptive deficits in people with low back pain (LBP) have traditionally been attributed to altered paraspinal muscle spindle afference and its central processing. Studies conducted in the upper limb demonstrated that sense of effort is also an important source of kinaesthetic information.

To better understand proprioceptive deficits in people with chronic LBP (cLBP), this study aimed to test whether sense of effort is affected in people with cLBP.

Cross-sectional study.

Fourteen participants with cLBP and fourteen healthy participants performed a 120s force matching task with their trunk extensor muscles at a low intensity.

When visual feedback of the generated force was provided, both groups performed the task accurately. Removal of visual feedback resulted in an increase in error for both groups (p<0.0001), but the increase in error was significantly larger for the cLBP group (p=0.023). This larger error could be attributed to undershooting of the target force (p=0.020). The control group did not consistently undershoot or overshoot the target force (p=0.