Peak-to-trough ratios in the repeated-dose study ranged from 1.3-1.4 with once-weekly dosing and 5.9-12.9 with once-monthly dosing. Following a single dose of efpeglenatide 14-100 μg/kg, FPG and PPG levels were decreased at week 1 and remained below baseline levels for ≥3 weeks post-dosing. Repeated doses of efpeglenatide led to significant redu…[Read more]

Prostate cancer (PCa) is the second most diagnosed type of cancer in men worldwide. Advanced PCa is resistant to conventional therapies and high recurrence has been associated with high rates of metastasis. Cancer stem cells (CSCs) have been proposed to be responsible for this, due to their ability of self‑renewal and differentiation into other c…[Read more]

Background Vascular smooth muscle cells (VSMC) underwent phenotypic switching upon stimulation signals, and this is the prerequisite for their proliferation and migration. Previous work revealed that miR-455 may be involved in vascular stenosis. Thus, this study aimed to explore potential targets and mechanisms underlying the dynamics of miR-455…[Read more]

(1,3)-β-D-glucan (BD) assays were developed as a method to rapidly diagnose invasive candidiasis (IC). The incidence of fungal infections and the demands for BD assay are gradually increasing in patients with severe trauma and under intensive care. However, the ideal BD cut-off value to predict IC has not been clarified. In this study, we…[Read more]

aeruginosa MDR clone (ST3079), a novel A. baumannii clonal profile circulating in Brazil (ST848), and important resistance associations in the form of bla VIM-2 and bla IMP-56 being found together in one ST233 strain, stand out. Such findings may help to develop approaches to deal with BSI and even other nosocomial infections caused by these…[Read more]

In recent years, there has been an increase in the descriptions of members of the lizard genus Lepidophyma. Herein, we describe a new species of Lepidophyma from the Huasteca Potosina region of Mexico, previously confused with L. gaigeae, from which it differs in lacking parietal spot, among other characteristics. We inferred its phylogenetic…[Read more]

Blockchain has been applied to quality control in manufacturing, but the problems of false defect detections and lack of data transparency remain. This paper proposes a framework, Blockchain Quality Controller (BCQC), to overcome these limitations while fortifying data security. BCQC utilizes blockchain and Internet-of-Things to form a…[Read more]

Blockchain has been applied to quality control in manufacturing, but the problems of false defect detections and lack of data transparency remain. This paper proposes a framework, Blockchain Quality Controller (BCQC), to overcome these limitations while fortifying data security. BCQC utilizes blockchain and Internet-of-Things to form a…[Read more]

Schizophrenia is a serious mental illness that causes great harm to patients, so timely and accurate detection is essential. This study aimed to identify a better feature to represent electroencephalography (EEG) signals and improve the classification accuracy of patients with schizophrenia and healthy controls by using EEG signals. Our research…[Read more]