The highest FGF-21 quartile was associated with worse SPPB and HAQ. Higher baseline FGF-21 levels (per 1 SD) were associated with worsening in muscle density and area Z-scores (β -0.06, 95% CI -0.12 to 0.008,

= 0.08; and β -0.05, 95% CI -0.10 to 0.006,

= 0.08, respectively) and a greater probability of a clinically meaningful worsening o…[Read more]

Effects of maternal GDM, prepregnant obesity, and gestational weight gain on children’s BMI and BMI trajectories from birth to preschool age differed in relation to effect size, timing and direction.

Effects of maternal GDM, prepregnant obesity, and gestational weight gain on children’s BMI and BMI trajectories from birth to preschool age…[Read more]

Emerging research has examined the prevalence of severe acute respiratory syndrome virus 2 (SARS-CoV-2) infections in numerous settings, but a critical gap in knowledge is an understanding of the rate of infection among first responders.

We conducted a prospective serial serologic survey by recruiting public first responders from Cleveland…[Read more]

ognostic indicator in GC patients with good prognosis or normal biochemical indexes, including no peritoneal infiltration, normal neutrophil counts, and normal serum sodium and globulin levels (all p less then 0.001). Conclusions Overall, our findings indicate that SGR is a novel and promising prognostic factor for GC patients. It has superior…[Read more]

Nanostructured lipid carriers (NLC) have become a research hotspot, wherein cancer-targeting effects are enhanced and side effects of chemotherapy are overcome. Usually, accelerated blood clearance (ABC) occurs after repeated injections, without changing the immunologic profile, despite PEGylation which prolongs the circulation function. To…[Read more]

Pulmonary metastasis was promoted and the expressions of FSP1 and GFP were increased in mice with pulmonary fibrosis. CM enhanced the invasion and inhibited the apoptosis of tumor cells. SiZEB1-AS1 and siZEB1 inhibited the invasion and apoptosis of tumor cells, while miR-200b-3p inhibitor had the opposite effect of SiZEB1-AS1 and siZEB1, and…[Read more]

This study aimed at investigating the anticancer activity of an exopolysaccharide (EPS) isolated from Lactobacillus helveticus MB2-1. The crude EPS from L. helveticus MB2-1 (LHEPS) was fractionated into three fractions, namely LHEPS-1, LHEPS-2 and LHEPS-3. LHEPS-1 exhibited the most effective anti-proliferative activity, which was associated with…[Read more]

5%, pylorus preserving pancreaticoduodenectomy (PpPD) 4.2%, Billroth-II gastrectomy (B-II) 11.6%, and other reconstruction method (others) 7.4%. The contributing factors calculated by a multivariate analysis were B-II (odds ratio [OR] 1.864, 95% confidence interval [CI] 1.001-3.471, p = 0.050), and the presence of naïve papilla (OR 3.268, 95% CI…[Read more]

Metabolic syndrome (MetS) is usually associated in general population with systemic inflammation and higher cardiovascular risk, but data about the effect of statins in patients with HIV infection and MetS are lacking to date.

Prospective cohort study of treated HIV-infected patients, aged from 40 to 60 years, with or without MetS, who s…[Read more]

Optimization of chances for healthy offspring is thought to be one of the factors driving mate choice and compatibility of the major histocompatibility complex (MHC) is assumed to determine the offspring’s fitness. While humans have been claimed to be able to perceive information of MHC compatibility via the olfactory channel, it remains unknown…[Read more]

Current drug discovery efforts focus on identifying lead compounds acting on a molecular target associated with an established pathological state. Concerted molecular changes that occur in specific cell types during disease progression have generally not been identified. Here, we used constellation pharmacology to investigate rat dorsal root…[Read more]

Current drug discovery efforts focus on identifying lead compounds acting on a molecular target associated with an established pathological state. Concerted molecular changes that occur in specific cell types during disease progression have generally not been identified. Here, we used constellation pharmacology to investigate rat dorsal root…[Read more]