The proteins were overexpressed, purified, and characterized due to their biochemical properties. All mutants exhibited differing Michaelis-Menten behavior towards l-selenocysteine, but His-100 was not found is essential for this task. Additionally, l-cysteine acted as a competitive inhibitor of most enzymes with greater affinity than…[Read more]

Gene-specific biomarkers such as PGRN in GRN mutation carriers and dipeptide repeat proteins in C9orf72 mutation companies tend to be possible target engagement markers in genetic FTD trials. Novel practices with the capacity of measuring really low concentrations of brain-derived proteins in peripheral liquids are facilitating scientific studies…[Read more]

Streptococcus suis is a zoonotic pathogen causing severe attacks in swine and humans. Although metals are essential for a lifetime, excess amounts of metals tend to be toxic to micro-organisms. Transcriptome-level information for the components for weight to steel toxicity in S. suis are for sale to no metals other than zinc. Herein, we explored…[Read more]