We performed retrospective human clinical studies in two independent cohorts. In the Dijon cohort,

seropositivity was found to be associated with a decreased NSCLC patient survival on anti-PD-1 therapy. The survival median for

seropositive patients was 6.7 months compared with 15.4 months for seronegative patients (p=0.001).…[Read more]

© 2020. Published by The Company of Biologists Ltd.Eric Olson is Professor and Chair of Molecular Biology at the University of Texas Southwestern Medical Center, USA, where he holds the Robert A. Welch Distinguished Chair in Science, the Annie and Willie Nelson Professorship in Stem Cell Research and the Pogue Distinguished Chair in Research in…[Read more]

Subcellular localization analysis showed that CiIRF8 is located both in the cytoplasm and nucleus; however, CiIRF2 is only located in the nucleus. The nuclear-cytoplasmic translocation of CiIRF8 was observed in CIK cells under stimulation with poly(IC). The interaction of CiIRF8 and CiIRF2 was further confirmed by a co-immunoprecipitation assay in…[Read more]