With a compact neural circuit consisting of entirely mapped 302 neurons, Caenorhabditis elegans plays an important role in the development and application of optogenetics. Optogenetics in C. elegans offers the opportunity that drastically changes experimental designs with increasing accessibility for neural activity and various cellular processes,…[Read more]

In summary, this study demonstrates the saliency of social information in intrinsic motivational processes that underpin success-failure outcomes.Neurologic damage often leads to neuropathic pain, for which there are no effective treatments owing to its complex pathogenesis. The purinergic receptor P2X4 is closely associated with neuropathic pain.…[Read more]

To compare the histological and angiographic measurements of the basilar artery in an experimental rabbit subarachnoid hemorrhage model.

The basilar artery was measured using both histological and angiographic methods in experimental subarachnoid hemorrhage (SAH) and vasospasm rabbit models. New Zealand white rabbits were randomly…[Read more]

Most genetic variants for colorectal cancer (CRC) identified in genome-wide association studies (GWAS) are located in intergenic regions, implying pathogenic dysregulations of gene expression. However, comprehensive assessments of target genes in CRC remain to be explored. We conducted a multi-omics analysis using transcriptome and/or DNA…[Read more]

Water, the most abundant compound on the surface of the Earth and probably in the universe, is the medium of biology, but is much more than that. Water is the most frequent actor in the chemistry of metabolism. Our quantitation here reveals that water accounts for 99.4% of metabolites in Escherichia coli by molar concentration. Between a third and…[Read more]

The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigate the long-term clinical outcomes of this strategy in comparation to surgical resection.

Stage II/III rectal adenocarcinoma patients…[Read more]

Plant complex sterility agent with high concentration can effectively target rat sperm gene DPY19L2 and realize effective sterility control of rat pests.

The changes in the electrolyte profiles in patients with diabetic ketoacidosis (DKA) have rarely been reported. This study reports the abnormalities in the electrolyte profile, such as serum…[Read more]

To analyse the factors associated with length of stay (LOS) and death in nasogastric/nasoenteric tube (NG/NET)-fed patients.

A cross-sectional multicentre study.

Data collection took place from October 2017-April 2019, and the sample consisted of 365 participants from seven Brazilian hospitals. Demographic, clinical and therapeutic…[Read more]

Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in cancer development and progression. However, the general regulatory mechanism of FoxM1 is still limited. STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules. It was reported…[Read more]