KEY FINDINGS Meriolin1 could exert the antitumour activity on SH-SY5Y cells by inducing cell cycle arrest, cell autophagy, the mitochondrion-dependent cell apoptosis and targeting the Akt/MAPKs signalling pathway. CONCLUSIONS Meriolin1 might be a promising therapeutic candidate for neuroblastoma. © 2020 Royal Pharmaceutical Society.INTRODUCTION…[Read more]

To estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people with cancer.

We employed near real-time weekly data on cancer care to determine the adverse effect of the pandemic on cancer services. We also used these data, together with national death registrations until…[Read more]

5% subjects diagnosed with ADHD as primary diagnosis. Detection of CNVs of unknown clinical significance was similar in the two groups being 27% and 32% respectively. Benign and likely benign CNVs accounted for 61% and 59.5% in the first and second group respectively. Differences in the diagnostic yield were not statistically significant between…[Read more]

Successful endovenous thermoablation relies on transmural vein wall ablation. We investigated the pattern of thermal spread and tissue carbonisation from RadioFrequency-induced ThermoTherapy (RFiTT) at different powers and pull back methods, using a porcine liver model.

We used a previously validated

porcine liver model. Different…[Read more]

Elevation, Mean UV-B of Lowest Month, Precipitation of Coldest Quarter, and Mean Temperature of Driest Quarter were major factors determining the section’s distribution. Our modeling indicated that Clematis sect. Fruticella underwent a significant range contraction during the last interglacial period, and then expanded during the last glacial…[Read more]

Elevation, Mean UV-B of Lowest Month, Precipitation of Coldest Quarter, and Mean Temperature of Driest Quarter were major factors determining the section’s distribution. Our modeling indicated that Clematis sect. Fruticella underwent a significant range contraction during the last interglacial period, and then expanded during the last glacial…[Read more]

52 (2.24-18.95) compared with those without elevation in any of 4 biomarkers. The simultaneous inclusion of all 4 biomarkers to the conventional model significantly improved discrimination (C statistic increased from 0.702 to 0.748, P=0.004) and risk reclassification (net reclassification improvement 45.0%; integrated discrimination improvement…[Read more]

MHC class I polypeptide-related sequence A (MICA) is a stress-induced protein involved in activation of NK and T cells through interaction with NKG2D receptor. These molecules are atypically expressed in synovium of patients diagnosed with rheumatoid arthritis (RA). A total of 279 patients with RA, qualified to TNF-blockade therapy, were genotyped…[Read more]