It is hoped that this article will also set a stage for expanded efforts in the identification, characterization, and functional interrogation of plant sirtuins; and the development and exploration of their chemical modulators (activators and inhibitors) in plant research and agriculture. Iron (Fe) is an essential micronutrient for plant life and…[Read more]

Metastasis is a major cause of high recurrence and poor survival of patients with colorectal cancer (CRC), although the mechanisms associated with this process remain poorly understood. In this study, we report a novel mechanism by which SOX13 promotes CRC metastasis by transactivating SNAI2 and c-MET. SOX13 overexpression was significantly…[Read more]

Students with lower need of cognitive closure successfully learned to build a good relation with the patient.

The study allows a better understanding of the phenomena occurring during the learning of clinical interview skills with the use of a VP.

The study allows a better understanding of the phenomena occurring during the learning of…[Read more]

OBJECTIVE This study aims to evaluate the efficacy and safety of the addition of 10 or 25 mg of empagliflozin to patients with type 2 diabetes mellitus using a maximum tolerable dose of metformin and gliclazide. METHODS A total of 60 patients who had been receiving a maximum tolerable dose of metformin plus gliclazide. was divided into two groups…[Read more]

Background Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. It was determined that circular RNAs were related to the development and progression of various cancers, including OSCC. The purpose of our study was to figure out the role and potential mechanism of hsa_circ_0072387 in OSCC progression. Materials…[Read more]

The nasal administration of GER-UDCA-SLNs (1 mg/kg of GER-UDCA) allowed to detect the prodrug in rat cerebrospinal fluid (concentration range = 1.1 to 4.65 μg/mL, 30-150 min after the administration), but not in the bloodstream, thus suggesting the direct nose to brain delivery of the prodrug. Finally, histopathological evaluation demonstrated…[Read more]

Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.A self-care movement for social workers is beginning to embrace mindfulness and other forms of wellness. However, self-care is often framed as…[Read more]

PURPOSE Evaluate impact of physician referral to health coaching on patient engagement and health risk reduction. DESIGN Four-year retrospective, observational cohort study with propensity-matched pair comparisons. SETTING Integrated delivery and finance system in Pittsburgh, Pennsylvania. SAMPLE 10 457 adult insured members referred to health…[Read more]