We undertook an early phase II study of mixed 19-peptide cancer vaccine monotherapy for 14 advanced metastatic triple-negative breast cancer (mTNBC) patients refractory to systemic chemotherapy to develop a new type of cancer vaccine. The treatment protocol consisted of a weekly vaccination for 6 weeks, and there were no severe adverse events…[Read more]

Preexposure prophylaxis (PrEP) is highly effective in preventing HIV among both men and women, with the reduction in risk directly linked to medication adherence. Navigation services and other adherence interventions have demonstrated efficacy in medication uptake; however, their use may not be fully integrated into clinic operations or their…[Read more]

The amount of itraconazole in nail clippings was quantified hereafter using a validated HPLC method. RESULTS Statistical analysis showed that itraconazole transungual permeation was not influenced by the studied monoterpenes (P value > .05). CONCLUSION These results provided a new perspective for designing topical dosage forms for the treatment of…[Read more]

8% for the ADHERE model and from 46.7% for the ADHF/NT-proBNP risk score to 42.1% for the ASCEND risk score, respectively. There was a modest agreement between the risk scores in classifying the patients across risk strata or in classifying those who died as being at >30% risk of death. Conclusion Although risk assessment tools work well for…[Read more]