egistration The trial was registered in ClinicalTrials.gov in April 2014, Identifier NCT02136368. Hydroxychloroquine Copyright © 2020 Boa Sorte Silva, Nagamatsu, Gill, Owen and Petrella.Connections between neurons called synapses are the key components underlying all nervous system functions of animals and humans. However, important genetic…[Read more]

Acute pancreatitis (AP) is an inflammatory gastrointestinal disorder affecting the pancreas. Previous study reported that tetraspanin 1 (TSPAN1) expression was significantly upregulated in the pancreas of AP patients. However, the underlying molecular mechanism of TSPAN1 in the pathogenesis of AP remains unclear. Thus, the aim of the present study…[Read more]

The majority of patients with laboratory-confirmed 2019-nCoV infection or suspected infection were female (23 [62%] of 37), and the mean age was 41.0 years old (standard deviation 19.6; range 4-78). 10 (27%) patients had chronic medical illnesses, including 4 (11%) with diabetes, 8 (22%) with hypertension, and 8 (22%) with digestive system…[Read more]

Using high-fidelity micromanometers and flow velocity sensors at right heart catheterization, we compared pulmonary hemodynamics and wave reflections in age-matched normal adults and those with atrial septal defects, separated into three subgroups based on levels of mean pulmonary artery pressure low ( 26 mmHg). We made baseline measurements in…[Read more]

Pharmacological analyses showed that phosphorylated/activated p65 downregulates miR-124 via two signaling pathways (1) TAK1/IKKα-IKKβ/IκBα and (2) MAPK/p65. Moreover, ChIP assay demonstrated that p65 directly regulates miR-124 by binding to the NF-κB consensus sequence in its promoter region. Finally, we also confirmed that stable ectopic expr…[Read more]

Retraction “Effects of long non-coding RNA HOST2 on cell migration and invasion by regulating MicroRNA let-7b in breast cancer,” by Peng-Wei Lu, Lin Li, Fang Wang, Yuan-Ting Gu, J Cell Biochem. 2018; 4570-4580 The above article, published online on 13 December 2017 in Wiley Online Library (https//onlinelibrary.wiley.com/doi/10.1002/jcb.26606) has…[Read more]

In this work, particles of activated carbon supported by Fe-N-TiO2 (Fe-N-TiO2/AC) were synthesized and used as the three-dimensional (3D) particle electrode for folic acid wastewater treatment in the 3D electrolysis and photocatalysis coupling process. The structure, morphology, and physical and electrochemical properties of the Fe-N-TiO2/AC…[Read more]

We found EqPV-H shedding in oral and nasal secretions, and in feces. Importantly, we could demonstrate EqPV-H transmission via oral inoculation with viremic serum. Together, our findings provide additional information that EqPV-H is the likely cause of Theiler’s disease and that transmission of EqPV-H occurs via both iatrogenic and natural…[Read more]

Rubus coreanus Miquel (Bokbunja), a Korean black raspberry, is known to possess various phytochemicals exerting the effect on oxidation, inflammation, and cancer. However, most of studies have been performed with the solvent extracts and/or the single component to demonstrate the efficacy, and the study evaluating the effect of the whole fructus…[Read more]

BACKGROUND The prostate-specific phosphatase and tensin homolog deleted on chromosome 10 (Pten) gene-conditional knockout (KO) mouse carcinogenesis model is highly desirable for studies of prostate cancer biology and chemoprevention due to its close resemblance of primary molecular defect and many histopathological features of human prostate…[Read more]

This case demonstrates that the SP robot can be used for splenectomy to eliminate the risk of splenosis and achieve a superior cosmetic result.

This case demonstrates that the SP robot can be used for splenectomy to eliminate the risk of splenosis and achieve a superior cosmetic result.

This study aimed to identify high-risk factors for…[Read more]

Quinine, a cinchona bark-derived antimalarial alkaloid, is a known ototoxic. Isolated and named in 1820 by the French scientists Pierre-Joseph Pelletier and Joseph-Bienaimé Caventou, it has since been employed in the treatment of different maladies. Quinine was also recommended as a local anesthetic in surgical procedures in the early 20th…[Read more]