Every cell in the human body has a unique set of somatic mutations, but it remains difficult to comprehensively genotype an individual cell1. Here we describe ways to overcome this obstacle in the context of normal human skin, thus offering a glimpse into the genomic landscapes of individual melanocytes from human skin. As expected, sun-shielded…[Read more]

In addition, circPRKCI negatively regulated the expression of miR-545, and miR-545 up-regulation reversed the inhibiting effects of circPRKCI overexpression on LPS-induced HK2 cell injury. Moreover, zinc finger E-box-binding homeobox 2 (ZEB2) was identified as a target gene of miR-545, and ZEB2 overexpression partly reversed the effects of miR-545…[Read more]

Nintedanib slows disease progression in patients with Idiopathic Pulmonary Fibrosis (IPF) by reducing decline in Forced Vital Capacity (FVC). The effects of nintedanib on abnormalities on high-resolution computed tomography scans have not been previously studied.

We conducted a Phase IIIb trial to assess the effects of nintedanib on…[Read more]

The combustion behaviours of three components, namely hemicellulose, cellulose, and lignin, and four types of biomass, namely rice straw, bamboo, peanut shell, and chestnut shell, were examined in a drop tube furnace set at 1273 K, in O2/N2 atmospheres containing 21-100% O2. Radiant energy analysis technology was employed to infer the temperatures…[Read more]