Response styles, the general tendency to use certain categories of rating scales over others, are a threat to the reliability and validity of self-report measures. The mixed partial credit model, the multidimensional nominal response model, and the item response tree model are three widely used models for measuring extreme and midpoint response…[Read more]

Previous studies showed increasing number of children with a life-limiting or life-threatening condition who may benefit from input from pediatric palliative care services.

To estimate the current prevalence of children with a life-limiting condition and to model future prevalence of this population.

Observational study using…[Read more]

45% and 20.63% (HR 0.87; 95% CI, 0.605-1.236), and 7.48% and 9.52% (HR 0.78; 95% CI, 0.461-1.350) patients in the sacubitril/valsartan and enalapril group, respectively. The all-cause mortality (19.0% vs. 21.9%) and adverse events (78.4% vs. 82.2%) were comparatively lower in the sacubitril/valsartan than enalapril group. No significant difference…[Read more]

This shows that the auto-inhibition effects are unique to nerve terminals. We further determined that serotonin released from peri-synaptic dense-core vesicles contributes to auto-inhibition in the terminals, since blockade of L-type calcium channels, which are required to stimulate extrasynaptic but not synaptic release, decreased the amplitude…[Read more]

Findings are consistent with the possibility that early calibration to ecological unpredictability, but not harshness, undermines other-oriented psychological processes which, in turn, reduce moral concerns about harm and consequences for other people. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Wives are usually younger than…[Read more]

NCS-loaded PM functionalized with an antibody fragment against CD44v6 (Fab-CD44v6) presented adequate size, charge, and encapsulation efficiency. In addition, Fab-CD44v6 significantly increased PM internalization in CD44v6+ cells. Further, encapsulation of NCS improved its effectiveness in vitro, particularly against colonspheres, and allowed to…[Read more]