Glucocorticoid receptor (GR) is a key homeostatic regulator involved in governing immune response, neuro-integration, metabolism and lung function. In conjunction with its pivotal role in human biology, GR action is critically linked to the pathology of various disease types, including cancer. While pharmacological activation of GR has been used…[Read more]

The 3-year LFS were 58 %, 62 % and 25 % for patients within ELN favorable-, intermediate-, and adverse-risk groups respectively. Twenty-seven (36 %) out of 75 patients with intermediate- and adverse-risk disease underwent allogeneic hematopoietic cell transplantation (allo-HCT) in first CR with 92 % of them receiving post-transplant maintenance…[Read more]

Cognitive impairment is a part of the spectrum of SCA12 and is characterized by dysfunction in executive function and new learning ability even early in the course of disease.

Cognitive impairment is a part of the spectrum of SCA12 and is characterized by dysfunction in executive function and new learning ability even early in the course of…[Read more]

OBJECTIVE To evaluate whether teaching mothers about neonatal jaundice will decrease the incidence of acute bilirubin encephalopathy among infants admitted for jaundice. STUDY DESIGN This was a multicenter, before-after and cross-sectional study. Baseline incidences of encephalopathy were obtained at 4 collaborating medical centers between January…[Read more]

ic stability of this promising radiopeptide.Recently, exploring brain activity based on functional networks during naturalistic stimuli especially music and video represents an attractive challenge because of the low signal-to-noise ratio in collected brain data. Although most efforts focusing on exploring the listening brain have been made…[Read more]

To examine the association between geographic atrophy (GA) disease characteristics and mortality risk.

We manually delineated color fundus photographs of 209 Age-Related Eye Disease Study (AREDS) participants with GA secondary to age-related macular degeneration to identify total area of atrophy, GA effective radius growth rate, disease…[Read more]

The vertical intensity distribution of synchrotron-based X-ray beams usually has a Gaussian profile encompassing large intensity variations. For biomedical imaging applications this may entail sub-optimal dose distributions and large fluctuations in terms of image noise. Commonly, planar metallic filters coupled with absorbing slits systems are…[Read more]

Machine learning (ML) methods still have limited applicability in personalized oncology due to low numbers of available clinically annotated molecular profiles. This doesn’t allow sufficient training of ML classifiers that could be used for improving molecular diagnostics.

We reviewed published datasets of high throughput gene expression…[Read more]

Machine learning (ML) methods still have limited applicability in personalized oncology due to low numbers of available clinically annotated molecular profiles. This doesn’t allow sufficient training of ML classifiers that could be used for improving molecular diagnostics.

We reviewed published datasets of high throughput gene expression…[Read more]

AIMS The objective of this study was to investigate farmers’ perception of lameness in comparison to the estimated prevalence of lameness in NSW pasture-based dairies to evaluate farmers’ perceptions and approaches to detection, treatment and prevention of lameness. METHODS Across-sectional study was conducted on 62 pasture-based dairy farms…[Read more]

Furthermore, the design strategy of HCMs is expected to provide a novel guidance for the design of multi-layer carbon structure with improved electrochemical properties.For the realization of the economical and reliable fabrication process of molybdenum disulfide (MoS²) layers, MoS² thin films were directly formed a on soda-lime glass substrate b…[Read more]

The electrochemical reduction of CO2 (ECO2R) is a promising method for reducing CO2 emissions and producing carbon-neutral fuels if long-term durability of electrodes can be achieved by identifying and addressing electrode degradation mechanisms. This work investigates the degradation of gas diffusion electrodes (GDEs) in a flowing, alkaline CO2…[Read more]