The matching algorithm resulted in 530 patients for the final analysis, 265 patients in each group. There were no significant differences between the groups in terms of age, BMI, smoking, gender, race, sleep apnea, or diabetes. A paired t test found no significant differences between the MWM group and the control group at 1 year in both total…[Read more]

Cortical arousal from sleep is associated with autonomic activation and acute increases in heart rate. Arousals vary considerably in their frequency, intensity/duration, and physiological effects. Sleep and arousability impact health acutely (daytime cognitive function) and long-term (cardiovascular outcomes). Yet factors that modify the arousal…[Read more]

The non-polar extracts of E. clavarioides exhibited the highest cell growth inhibition activity with hexane extract reaching IC50 at 1 μg mL-1. The DCM extract of E. caerulescens reached IC50 at a concentration of 10 μg mL-1, while other extracts didn’t show any activity. The hexane and DCM extracts of E. polygona exhibited the highest cell g…[Read more]

Accumulating evidence points to a significant link between disrupted circadian rhythms and neuronal disfunctions, though the molecular mechanisms underlying this connection are virtually unexplored. 2-Hydroxybenzylamine The transcript Homer1a, an immediate early gene related to postsynaptic signaling, has been demonstrated to exhibit robust…[Read more]