In recent years, the efficacy of type 2 diabetes mellitus (T2DM) drugs in the treatment of Alzheimer’s disease (AD) has attracted extensive interest owing to the close associations between the two diseases.

Here, we screened traditional Chinese medicine (TCM) and multi-target ingredients that may have potential therapeutic effects on both…[Read more]

Mascarpone, a soft-spread cheese, is an unripened dairy product manufactured by the thermal-acidic coagulation of milk cream. Due to the mild flavor and creamy consistency, it is a base ingredient in industrial, culinary, and homemade preparations (e.g., it is a key constituent of a widely appreciated Italian dessert ‘Tiramisù’). Probably due to…[Read more]

Mechanical and pharmacological conditioning can significantly enhance the regenerative properties of mesenchymal stem cells.The detection and quantification of protein biomarkers in interstitial fluid is hampered by challenges in its sampling and analysis. Here we report the use of a microneedle patch for fast in vivo sampling and on-needle…[Read more]

At higher concentration where the CUP reached the gel point the rate of diffusion controlled the evaporation. The final drying point was the loss of three waters of hydration for each carboxylate on the CUP surface.The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with…[Read more]

This work is of great significance for the development of new antibacterial nanomaterials derived from natural biomass as well as the treatment of infections caused by Gram-negative bacteria.3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is a metabolite of furan fatty acids found in plasma and urine of humans after consumption of foods…[Read more]

How does memory for the public past differ from memory for the personal past? Across five experiments (N = 457), we found that memories of the personal past were characterised by a positivity bias, whereas memories of the public past were characterised by a negativity bias. This valence-based dissociation emerged regardless of how far back par…[Read more]

4% vs. 39.3% (P > 0.05). Short-term complications ranged from minor to major leakages, cavity infection and abscess formation, and prevalence was 17.4% vs. 21.4% (P > 0.05) respectively for double and single T-tube groups; most importantly, double T-tube drainage group had obvious advantages regarding long-term complications (P <…[Read more]