Potentiation of glutamatergic synaptic transmission is thought to underlie memory. The induction of this synaptic potentiation relies on activation of NMDA receptors which allows for calcium influx into the post-synapse. A key mechanistic question for the understanding of synaptic potentiation is what signaling is activated by the calcium influx.…[Read more]

001). The RFS rates at 1, 3, 5, and 10 years after microwave ablation were 96.3%, 75.2%, 55.4%, and 30.4% in patients with high-PNI levels, and 94.4%, 48.8%, 36.4%, and 13.1% in patients with low-PNI levels, respectively (P<0.001). In multivariate analyses, preoperative PNI level was an independent prognostic factor for both OS and RFS.…[Read more]

If the tendency to discount rewards reflects individuals’ general level of impulsiveness, then the discounting of delayed and probabilistic rewards should be negatively correlated The less a person is able to wait for delayed rewards, the more they should take chances on receiving probabilistic rewards. It has been suggested that damage to the…[Read more]

To characterize the effective connectivity (EC) between the emotion and motor brain regions in patients with psychogenic nonepileptic seizures (PNES), based on resting-state spectral dynamic causal modeling (spDCM).

Twenty-three patients with PNES and twenty-five healthy control (HC) subjects underwent resting-state fMRI scanning. The…[Read more]

Ghrelin levels in the aGHD group were significantly lower than in healthy controls. In contrast, LEAP-2 showed a trend toward higher levels, although the differences were not significant. However, the LEAP-2/Ghrelin ratio was significantly higher in aGHD. No significant correlations between ghrelin and LEAP-2 with BMI and HOMA index were found in…[Read more]

The duration of radiation therapy was 1 week and 3 days. The frequencies of acute radiotherapy-related side effects were as follows GU grade 0 – 17.1%, grade I – 30.7%, grade II – 50.7%, grade III – 1.5%; and GI grade 0 – 62.4%, grade I-31.7%, grade II-5.9%, grade III-0%. None of the patients developed grade ≥ 4 acute toxicity.

SBRT with a…[Read more]

3%. On multivariate analysis, receiving adjuvant chemotherapy and low CRP levels on POD 7 (<7.6mg/dL) were prognosticators of better survival. However, the CD classification was not a prognosticator of survival after resection.

Adjuvant chemotherapy and postoperative low CRP levels on POD 7 were prognosticators of better survival of PDAC…[Read more]

manial drugs.

Based on the current study, these hits can be further structurally optimized and validated under laboratory conditions to develop antileishmanial drugs.A thorough study was undertaken of the synthesis of natural rubber-silica treated with bis-(3-triethoxysilylpropyl) tetrasulfane (NR/TSi) vulcanized using electron beam irradiation…[Read more]