The failure rate of operations involving the cephalomedullary nail technique for unstable femoral trochanteric fractures is 3-12%. Changing the reduction strategy may improve the stability. This study aimed to confirm whether reducing the proximal fragment with the medial calcar contact, as opposed to utilizing an intramedullary reduction, would…[Read more]

Our previous studies found that deletion of nuclear receptor interacting protein 1 (Nrip1) extended longevity in female mice and delayed cell senescence. The current study investigates the role of NRIP1 in regulating functions of adipose-derived mesenchymal stem cells (ADMSCs) and explores the mechanisms of NRIP1 in skin aging. We first verified…[Read more]

Crystallization and/or incubation of EstD11 at high temperature provided unique information on cap dynamics and a first glimpse of enzymatic activity in vivo. Very interestingly, we have discovered a unique Met zipper lining the active site and the cap domains that could be essential in pivotal aspects as thermo-stability and substrate promiscuity…[Read more]

Thirty patients for whom trans nasal endoscopy using Nasal Slider® could be carried out. Twenty-seven and 28 patients of all patients used Nasal Slider® expressed feeling less nasal discomfort and pain compared to an examination without Nasal Slider®. No epistaxis was detected in all patients using Nasal Slider®.ConclusionsTo reduce nasal pain and…[Read more]

This work elucidates the influence of both the temperature bias and the temperature range of phase transition on thermal rectification performance, which could incredibly benefit the evaluation and design of thermal diodes.Recently, the end-Devonian mass extinction (Hangenberg Crisis, 359 Ma) was identified as a first-order mass extinction, albeit…[Read more]

e highest (22%). When O3 pollution was substantial, the high relative humidity and low wind speed during the nighttime caused the concentration of NO2 and PM2.5 to rise significantly, and then the high temperatures during the day aggravated the complex nonattainment pollution.Based on the air pollution emission inventory technical methodology,…[Read more]

The prostate is a hormone-responsive organ where testicular androgens drive the proliferation and survival of prostatic cells, ensuring the development and functioning of this gland throughout life. Androgen deprivation therapy leads to apoptosis of prostatic cells and organ regression, and is a cornerstone of prostate cancer and benign prostatic…[Read more]

Using absolute liver attenuation <48 Hounsfield units (most likely reflective of the truth, given alanine aminotransferase distribution and body mass index data), the prevalence was 7% (n=42). Steatosis was reported for only 12 of 42 (28%) of these patients and was documented in clinical notes in only 3 of those cases.

Hepatic steatosis is…[Read more]

Pompe disease has a higher pGP (123,232) than earlier accepted (140,000). The pGP for Pompe disease was expectedly wide by population and consistent with previous reports based on newborn screening programs (approximately 110,000-130,000).

Pompe disease has a higher pGP (123,232) than earlier accepted (140,000). The pGP for Pompe disease was…[Read more]

Retinopathy development (OR 1.05 [95%CI 1.02-1.07] per mmol/mol increase) and progression (OR 1.05 [1.04-1.06]) at seven years was associated with higher HbA

atdiabetesdiagnosis. Obesity (OR 0.88 [0.79-0.98]) and high socioeconomic status (OR 0.63 [0.53-0.74]) were negatively associated with retinopathy development at seven years.…[Read more]