The results show clearly that a multi-protease approach allows to improve the identification and molecular characterization of small proteins and SEPs. LC-MS data ProteomeXchange PXD023921.An efficient nickel-catalyzed stereoselective asymmetric intramolecular reductive coupling of N-1,6-alkynones is reported. A P-chiral monophosphine ligand…[Read more]

The results show clearly that a multi-protease approach allows to improve the identification and molecular characterization of small proteins and SEPs. LC-MS data ProteomeXchange PXD023921.An efficient nickel-catalyzed stereoselective asymmetric intramolecular reductive coupling of N-1,6-alkynones is reported. A P-chiral monophosphine ligand…[Read more]

The spin-crossover (SCO) phenomenon is an active area of research. This paper describes the synthesis of an Fe-Ag Hofmann-type complex, Fe(4-methylpyrimidine)2[Ag(CN)2]2, which demonstrates a one-step SCO and single-layer Hofmann-type structure with Ag-N interactions and no Ag-Ag interactions, which is strikingly different from the previously…[Read more]

Lenvatinib combined with programmed cell death protein-1 (PD-1) inhibitors has resulted in good survival outcomes in the treatment of unresectable hepatocellular carcinoma (HCC). Hepatic artery infusion chemotherapy (HAIC) has also attracted attention due to its high response rates and favorable survival for advanced HCC patients. The present…[Read more]

Antimicrobial resistance (AMR) is a threat to animal and human health. Antimicrobial use has been identified as a major driver of AMR, and reductions in use are a focal point of interventions to reduce resistance. Prostaglandin E2 datasheet Accordingly, stakeholders in human health and livestock production have implemented antimicrobial…[Read more]

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary addition to the burgeoning field of immunotherapy. CAR T-cells are engineered by combining a T-cell receptor with the antigen-binding site of an immunoglobulin that allows the hybrid cell to target antigens of interest. CAR T-cell therapy has been approved to treat various…[Read more]