The mRNA relative transcription levels of ERα, progesterone receptor (PgR), DNA methyltransferase1 (Dnmt1), DNA methyltransferase3A (Dnmt3A), and DNA methyltransferase3B (Dnmt3B) were detected by real-time quantitative PCR (RT-qPCR). The ovary of female offspring with PND 56 was treated with bisulfite sequence PCR (BSP). Our results showed that, compared with the BPA group, 40 mg/kg CCFs significantly reduced the ovarian index of F1 females and the ovarian cytoapoptosis (P less then 0.01). CCFs also can alleviate the injure of the levels of serum hormone, hormone receptors, and DNMTs induced by BPA in F1 females at PND 21 and PND 56. Forty milligrams per kilogram of CCFs significantly inhibited the hypermethylation of the H19/Igf2 imprinted gene induced by BPA (P less then 0.01). It indicated that CCFs adjusted H19/Igf2 methylation by increasing the expression of DNMTs, thereby increasing the levels of reproductive hormones and receptors along with reducing the cytoapoptosis.For geological carbon sequestration, the reaction of aqueous CO2 with silicate rock permits carbonate formation, achieving permanent carbon sequestration. The fractures available in silicate rock provide significant surface area for the precipitation of carbonates. The experiments were performed in a batch tubular reactor under diffusion-limited condition, with a special arrangement of a narrow tube filled with a 2800 g/L dunite slurry. The tube was kept open from the top, standing vertically filled with a CO2-rich bulk solution under 1 barg CO2 and temperatures ranging from 25 to 75 oC for 7-30 days. After 7 days of the experiment, magnesite precipitation was seen inside the tube and the precipitation was continued for up to 30 days. The magnesite precipitation was identified by micro-Raman spectroscopy, X-ray diffraction, and scanning electron microscopy. Additionally, SiO2 formation was seen in relative close vicinity to the magnesite precipitation. The precipitation on the surface of silicate rock might cover the fractures and pore spaces available, which may over time reduce the dissolution rate of dunite. Graphical Abstract.This paper empirically examines the environmental Kuznets curve (EKC) hypothesis using a country’s water stress as an indicator of the pressure on renewable water resources. The sample consists of 9 European countries by covering the period 1995-2013. The paper adopts a panel threshold regression model which can predict the threshold level endogenously to analyze whether income per person has an impact on water stress. selleck The empirical findings strongly demonstrate the existence of a threshold beyond which environmental pressures of GDP (real) per capita growth on renewable water resources tend to increase. The growth below the threshold levels has no statistically significant effect on water stress, while the growth rate above the threshold increases stress on water resources. The available empirical findings obtained, albeit limited, tend not to support the EKC hypothesis, which postulates an inverted-U-shaped relationship.In support of the global efforts to tackle climate change, policy makers in the past decades have been actively involved, exploring possible options for ensuring low-carbon pattern of development. This study contributes to this important stream of policy discussion by using a newly developed econometric technique, dynamic ARDL simulations, to estimate and simulate the impact of bank credit to the private sector on aggregate carbon emissions and carbon emission intensity in Brazil over the period 1971-2014. The examined empirical model is based on a framework that incorporates the impact of population, economic growth, fossil energy intensity of consumption, and economic globalization. The analysis produced interesting results. First, the estimates show that economic growth and fossil energy intensity of consumption have significant long-run increasing impact on CO2 emissions in Brazil. Second, bank credit to the private sector has significant short-run and long-run reducing effects on aggregate CO2 emission and carbon emission intensity in the economy. Overall, the results reflect the tendency of the economy to become less carbon-intensive as bank credit supply to the private sector increases.In this paper, we present the studies on electromagnetic interference (EMI) shielding effectiveness (SE) of K2CrO4-PMMA composites developed by two different methods one in bulk form of thickness 1.2 mm and another by stacking twelve layers of thin films each of thickness 100 μm. The EMI SE of stacked twelve layers of 1.2-mm-thick composite films has been achieved until 23.2 dB in the frequency range 8.0-12.0 GHz. This is remarkably higher than the 17 dB achieved for the bulk composites of 1.2 mm thickness. The characteristic EMI SE graphs obtained using Agilent E82B Vector Network Analyzer in the X band frequency range have been depicted, and the shielding mechanism in these composites has been analyzed. It is found that the SE in this frequency range is dominated by absorption. The study suggests these composites to be a potentially promising material for EMI shielding purpose.Alzheimer’s disease (AD) is the most common neurodegenerative disease, and there has been no disease-modifying treatment for AD. Recent studies suggest that trehalose may have beneficial effect on neurodegenerative diseases through regulating autophagy and facilitating aggregated protein clearance. However, the effects of trehalose on AD-related neuropathologies are still unknown. Western blot was performed to examine the effects of trehalose on APP processing in vitro and in vivo. ELISA and immunohistochemical staining were conducted to measure Aβ production in vitro and neuritic plaque formation in APP23 transgenic mice, respectively. Trehalose treatment significantly decreased Aβ generation in HAW and 20E2 cells. Furthermore, trehalose treatment increased the levels of APP and its CTFs, and significantly reduced Aβ generation and neuritic plaque formation in APP23 mice. Our study showed that trehalose affected the APP processing both in vitro and in vivo and suggests that trehalose treatment may offer as a therapeutic strategy to ameliorate AD pathology by inhibiting Aβ generation and neuritic plaque formation.