Ethnopharmacological relevance Zicao is the dried root of Lithospermum erythrorhizon Sieb, et Zucc, Arnebia euchroma (Royle) Johnst, or Arnebia guttata Bunge and commonly used to treat viral infection, inflammation, arthritis and cancer in China.Shikonin (SKN) is a major active chemical component isolated from zicao. Previous reseach showed that…[Read more]

Instead, low serum T levels may predispose to endothelial dysfunction, thrombosis and defective immune response, leading to both impaired viral clearance and systemic inflammation. Obesity, one of the leading causes of severe prognosis in infected patients, is strictly associated with functional hypogonadism, and may consistently strengthen the…[Read more]

This discrepancy significantly varied by axis and surface, with the greatest discrepancy in the Z-axis of 0.30 mm (CI = [0.25, 0.35], p = 0.05) and on the superior surface of 1.30 mm (CI = [1.15, 1.45], p = 0.05). Single-slice acquisition was significantly more accurate than the helical protocol. CONCLUSIONS We found evidence of clinically…[Read more]

Germicidal lamps that emit primarily 254 nm ultraviolet radiation (UV) are routinely utilized for surface sterilization but cannot be used for human skin because they cause genotoxicity. As an alternative, 222 nm-UVC have been reported to exert sterilizing ability comparable to that of 254 nm-UVC without producing cyclobutane pyrimidine dimers…[Read more]

Unlike warfarin, direct factor Xa inhibitors do not need frequent blood monitoring and dose adjustment. We found that warfarin and other vitamin K inhibitors may promote the calcification of heart valves and coronary arteries. There is some evidence that direct factor Xa inhibitors may slightly reverse these calcifications in coronary arteries and…[Read more]

BACKGROUND The coatomer protein complex subunit beta 2 (COPB2) gene is upregulated and promotes cell proliferation in some cancer cells. This study aimed to investigate the role of microRNA (miRNA) targeting by COPB2 gene expression in human lung adenocarcinoma cell lines, including NCI-H1975 cells. MATERIAL AND METHODS COPB2 expression in normal…[Read more]

In water polo competitions, teams play four periods, each period consisting of eight minutes of actual playing time a total of 32 minutes (Standard Actual Play Time, SAPT). Substitutions are permitted and a player may be substituted several times. The aim of this article was to provide reference data on played time, taking into consideration the…[Read more]

The adoption of a shortened school week from the traditional 5 to 4 days is increasing nationwide. Budgetary and staffing needs are driving the change, yet research on the effects on students is lacking, especially regarding student health. Our study examined student health in 4 vs 5-day schools in Colorado, a state with one of the highest n…[Read more]

Omeprazole exposure decreased on concurrent administration with pexidartinib, the metabolite-to-parent ratio was similar following omeprazole administration alone vs coadministration with pexidartinib; pexidartinib did not affect CYP2C19-mediated metabolism. Maximum plasma concentrations of digoxin slightly increased (32%) with pexidartinib…[Read more]

To consolidate extant published evidence in relation to the potential of integrating oral healthcare for patients at risk of developing medication-related osteonecrosis of the jaw (MRONJ).

A critical synthesis and consolidation of five publications was undertaken. As a mechanism of situating the extant work within the context of primary…[Read more]