Medial meniscal root tears are biomechanically similar to a total meniscectomy. Repair is clinically indicated and supported by evidence. Increased contact pressures can result in cartilage degeneration and early onset of osteoarthritis. Once diffuse grade 3 or 4 osteoarthritis has settled in, repair may not be indicated anymore. Combining medial…[Read more]

Consistent with the observed signatures of decreased sleep quality, stress resistance and memory were impaired in Tfap2b mutant animals. Also, the circadian period was slightly shortened. Taken together, AP-2 transcription factors control sleep behavior also in mice, but the role of the AP-2 genes functionally diversified to allow for a…[Read more]