Burosumab treatment has demonstrated clinical improvement of rickets and growth in children, including during a randomized controlled trial compared with conventional therapy. Burosumab also improved pseudofracture healing in adults. Burosumab led to greater improvement in rickets and growth than conventional therapy. However, many questions…[Read more]

Bipolar disorder and major depression are associated with significant disability, morbidity, and reduced life expectancy. People with mood disorders have shown higher ratios of unhealthy lifestyle choices, including poor diet quality and suboptimal nutrition. Diet and nutrition impact on brain /mental health, but cognitive outcomes have been less…[Read more]

Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia and bipolar disorder. Previous studies have shown associations between SSRI treatment and cardiometabolic alterations. The aim of the present study was to investigate genetic variants associated with cardiometabolic adverse effects in patients…[Read more]

BACKGROUND Because internal temperature of tandir may reach up very high levels, tandir burns, which is one of flame burns, may cause more morbidity and mortality than those of other flame burns. Therefore, we aimed to compare tandir burns with other flame burns in the present study. METHODS In this study, we compared tandir burns with other flame…[Read more]

improve oral cancer screening rates among adults with PD.Although astragaloside IV protects from acute myocardial infarction (AMI)-induced chronic heart failure (CHF), the underlying mechanism of action is unclear. We determined the potential therapeutic effect of astragaloside IV using molecular docking approaches and validated the findings by…[Read more]

In phase I, there was no significant difference in the nasal loads of healthy horses (median (range) 2.04 × 10

copies/mL (0-2.44 × 10

)) and asthmatic horses in exacerbation (3.75 × 10

(0-4.84 × 10

); Wilcoxon’s rank sum test, P=.57).

N. semolina is commonly found in the airways of horses. The potential pathogenicity of N.…[Read more]

to effectively expade Tregs and help for RA patients’ symptoms remission without evaluated side effects.

Opioids are widely used in moderate-to-severe chronic pain which is non-responsive to standard analgesics. Prescriptions have increased in Europe in the last decade, although remain lower than in USA. This work projected the future…[Read more]

Use-wear analysis shows that Zhanqi community members were sophisticated creators of ceramic equipment, the ma’an cooking pot, which allowed them to prepare a wide number of dishes with limited fuel. These findings support recent isotope studies at Zhanqi as well as nuance the centrality of meat in the Siwa period diet.The foodborne pathogen…[Read more]

er agents will increase.

Use of metformin and newer glucose-lowering medication classes is increasing in patients with CKD with type 2 diabetes. We anticipate that percentages of patients with CKD using these newer agents will increase.Living with chronic kidney disease (CKD) is associated with hardships for patients and their care partners.…[Read more]