his work might also add insight to the pathophysiology of mental health conditions, and contribute to the current debate on the value of a transdiagnostic approach in psychiatry.

In solid tumours, antibiotic use during immune checkpoint inhibitor (ICI) treatment is associated with shorter survival. Following allogeneic haematopoietic cell…[Read more]

This Review describes the pathophysiological processes targeted by emerging therapies for OA, along with relevant clinical data and discussion of the main challenges for the further development of these therapies, to provide context for the latest advances in the field of pharmaceutical therapies for OA.The COVID-19 pandemic caused drastic…[Read more]

Physically meaningful characterization of irregularly shaped particles continues to present substantial challenges to the experimentalist. “Equivalent diameters” based on experimental techniques such as static and dynamic light scattering or sedimentation have proliferated to the point that they are often no longer recognized as equivalent. This…[Read more]

China’s rapid economic development since the late 1970s has resulted in a large-scale migrant population from rural to urban areas, with millions of Chinese children being left behind at home by their parents who migrated to city for work.

The primary objective of this study is to test the effects of family, school and background…[Read more]

d data over a wide range of dose-fractionation schemes. The same model, with only a few fitted parameters of clear mechanistic meaning, thus synthesizes both photon radiotherapy and CIRT clinical experience with early stage lung tumors.

To enable accurate magnetic resonance imaging (MRI)-based dose calculations, synthetic computed tomography…[Read more]

Angiogenesis requires coordinated endothelial cell specification, proliferation, and collective migration. The orientation of endothelial cell division is tightly regulated during the earliest stages of blood vessel formation in response to morphogenetic cues and the controlled orientation of the mitotic spindle. Consequently, oriented cell…[Read more]