The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in regulating DNA transcription, replication, and damage-repair among other nuclear functions. With this increased awareness, reinforced over the last ten years, many new experimental techniques, mainly based on microscopy and chromosome conformation capture, have…[Read more]

One of the most ambitious projects in communications in recent years is the development of the so-called satellite mega-constellations. Comprised of hundreds or thousands of small and low-cost satellites, they aim to provide internet services in places without existing broadband access. For the antenna subsystem, reflectarrays have been proposed…[Read more]

One of the most ambitious projects in communications in recent years is the development of the so-called satellite mega-constellations. Comprised of hundreds or thousands of small and low-cost satellites, they aim to provide internet services in places without existing broadband access. For the antenna subsystem, reflectarrays have been proposed…[Read more]

Although the benefits of disclosure are considerable, informing children with perinatal HIV of their own HIV status is often delayed to late adolescence. This study examined the social and contextual challenges that influence delaying disclosure to children and assessed the outcomes of delayed disclosure on the psychosocial health of children as…[Read more]

33 to 6.92 compared to standard therapy, yielding an ICER of 62,090 THB/QALY (1991 USD/QALY). Sensitivity analyses revealed that the addition of dapagliflozin to the standard treatment demonstrated an 87% cost-effectiveness strategy at a level of willingness to pay (WTP) of 160,000 THB/QALY (5131 USD/QALY). ICER was higher in non-diabetes compared…[Read more]

Understanding the causative epigenetic changes of loss-of-function has led to the development of novel therapeutic agents in cancer. DDR and related genes were found frequently methylated in human cancers, including BRCA1/2, MGMT, WRN, MLH1, CHFR, P16 and APC. Both genetic and epigenetic alterations may serve as synthetic lethal therapeutic…[Read more]