Side effects were similar to those previously reported, although more common and in some cases more severe and more prolonged than seen in the original trials. The impact of age, weight, and other confounding factors on development of side effects still needs to be elucidated.

Overall, onasemnogene appears to be efficacious in children older than seven months and well tolerated. Side effects were similar to those previously reported, although more common and in some cases more severe and more prolonged than seen in the original trials. The impact of age, weight, and other confounding factors on development of side effects still needs to be elucidated.

Emergency departments have seen altered patterns of attendance since the beginning of the COVID-19 pandemic, with reductions in the number of attendances for non-COVID-19 – patients. We assessed the use of the emergency department by frequent attenders during the height of the COVID-19 pandemic and explored any changes in emergency department attendance by this group.

As part of ongoing improvement work, we utilised a cohort design to evaluate the difference in patterns of attendance for the frequent attender group in a single centre. We created a 2019 ‘top attender’ cohort and a similar cohort for 2020. We compared admission patterns between the two time periods in order to understand the impact of the COVID-19 pandemic on this group.

Both groups were predominately male. Mental health and substance misuse use problems were common across both cohorts. The majority of patients lived in a socio-economically deprived areas. The median number emergency department visits in 2019, for the top attender cohort was 6 (IQR 4-9) vs 4 (IQR 2-7) for the top attender cohort of 2020 (p<.0013).

This single centre evaluation has shown a significant reduction in emergency department attendances for a frequent attender cohort in a single centre. Future work should investigate the longer-term impact which the COVID-19 pandemic has had on this patient group.

This single centre evaluation has shown a significant reduction in emergency department attendances for a frequent attender cohort in a single centre. Future work should investigate the longer-term impact which the COVID-19 pandemic has had on this patient group.T cell-based adoptive cell transfer therapy is now clinically used to fight cancer with CD19-targeting chimeric antigen receptor T cells. find more The use of other T cell-based immunotherapies relying on antigen-specific T cells, genetically modified or not, is expanding in various neoplastic diseases. T cell manufacturing has evolved through sophisticated processes to produce T cells with improved therapeutic potential. Clinical-grade manufacturing processes associated with these therapies must meet pharmaceutical requirements and therefore be standardized. Here, we focus on the use of cytokines to expand minimally differentiated T cells, as well as their standardization and harmonization in research and clinical settings.

There is limited evidence of the impact of cannabis legalization on the prevalence of cannabis use and use of other substances. The aim of this exploratory observational study was to compare rates of cannabis use, cigarette smoking, alcohol consumption, and the use of any street drugs during the preconception period and in pregnancy in two convenience samples of pregnant persons in British Columbia, Canada, before and after the legalization of cannabis.

Any pregnant person residing in British Columbia, aged >19 years, at any gestational age was eligible to participate. Pre- and post-legalization study participants were recruited between May and October 2018 and July 2019 and May 2020, respectively. Multivariate models were constructed to examine the effect of legalization on cigarette smoking and the use of cannabis, alcohol, and street drugs, adjusting for demographic, pre-pregnancy, and pregnancy confounders.

From pre- to post-legalization, the prevalence of self-reported cannabis use during the prinatal outcomes, as well as public health interventions and educational programs related to cannabis use, should include the preconception period as an area of focus.

The preliminary evidence presented in this study shows that the legalization of cannabis was associated with 71% higher odds of cannabis use during the preconception period. Studies examining the effects of cannabis use on perinatal outcomes, as well as public health interventions and educational programs related to cannabis use, should include the preconception period as an area of focus.The study of attentional processing in vision has a long and deep history. Recently, several papers have presented insightful perspectives into how the coordination of multiple attentional functions in the brain might occur. These begin with experimental observations and the authors propose structures, processes, and computations that might explain those observations. Here, we consider a perspective that past works have not, as a complementary approach to the experimentally-grounded ones. We approach the same problem as past authors but from the other end of the computational spectrum, from the problem nature, as Marr’s Computational Level would prescribe. What problem must the brain solve when orchestrating attentional processes in order to successfully complete one of the myriad possible visuospatial tasks at which we as humans excel? The hope, of course, is for the approaches to eventually meet and thus form a complete theory, but this is likely not soon. We make the first steps towards this by addressing the necessity of attentional control, examining the breadth and computational difficulty of the visuospatial and attentional tasks seen in human behavior, and suggesting a sketch of how attentional control might arise in the brain. The key conclusions of this paper are that an executive controller is necessary for human attentional function in vision, and that there is a ‘first principles’ computational approach to its understanding that is complementary to the previous approaches that focus on modelling or learning from experimental observations directly.