In organisms, activation of mitochondrial unfolded protein response (mt UPR) provides the protective strategy against toxicity of environmental exposures. Selleckchem ANA-12 The aim of this study was to determine the activation of intestinal mt UPR and the underlying mechanisms in nanopolystyrene (100 nm) exposed Caenorhabditis elegans. The…[Read more]

and IL-18 levels were evaluated using ELISA. The levels of NLRP3 inflammasome components and its upstream nuclear factor-κB (NF-κB) were determined using real-time PCR or Western blot. The experimental results indicated that posttreatment with Vinp decreased cerebral infarct size, improved behavior recover, reduced NLRP3 inflammasome expression, a…[Read more]

Dural sinus thrombosis (DST) is a potentially fatal neurological condition that can be reversed with early diagnosis and prompt treatment. paquinimod Non-enhanced CT scan is often the first imaging investigation in patients presenting with acute neurological symptoms; however, its poor sensitivity in detecting DST is a major drawback. Magnetic…[Read more]

Asthma and bronchiectasis are 2 heterogeneous diseases that frequently coexist, particularly in severe asthma. Recognition of this co-diagnosis may importantly affect treatment decisions and outcome. Previous studies in asthma with bronchiectasis show inconsistent outcomes, probably due to the heterogeneity of the included asthma cohorts.…[Read more]