05).

There was no significant increase in hemolysis among the groups, which demonstrates that the VAVD technique, even if lower negative pressure is preferred, can be applied safely and effectively to improve venous drainage and consequently, cardiac decompression, even if smaller venous cannulas are used, and also avoid from superfluous fluid addition to sustain adequate extracorporeal perfusion.

There was no significant increase in hemolysis among the groups, which demonstrates that the VAVD technique, even if lower negative pressure is preferred, can be applied safely and effectively to improve venous drainage and consequently, cardiac decompression, even if smaller venous cannulas are used, and also avoid from superfluous fluid addition to sustain adequate extracorporeal perfusion.Background It is well-known that the distribution of traditional cardiovascular risk factors (CVRFs) of atherosclerosis, including hypertension, dyslipidemia, smoking, obesity, and diabetes is considerably variable between different countries, however, with some important geographical trends. Thus, CVRFs contribute differently to atherosclerosis development in different countries. Common carotid artery intima-media thickness (CCA IMT) is a validated biomarker of subclinical atherosclerosis that is used in clinical and epidemiological studies to evaluate the impact of CVRFs on atherosclerosis development. Material and methods This comparative cohort study included a random sample of 1200 participants (n = 600 men and n = 600 women) from Moscow, Russia and Paris, France, aged between 55 and 79 years, and free of clinical symptoms of atherosclerosis. The study was conducted to determine the interpopulation variability of CCA IMT. CCA IMT was measured by ultrasonic scanning at the high-resolution regimen. Statisttively. In men of both Moscow and Paris study populations, the mean CCA IMT value was 0.84 and 0.67, respectively. In the Moscow study population, the effects (direct and indirect) of traditional CVRs can explain 42% of the CCA IMT variance in women and 30% – in men. In the Paris study population, direct and indirect effects of traditional CVRFs can explain 27% of the CCA IMT variance in men and 14% – in women. Conclusion The Paris study population significantly differed from the Moscow study population in the distribution and impact of traditional CVRFs. Traditional CVRFs can explain only a small proportion of the interpopulation differences in CCA IMT suggesting the presence of other factors, such as longitude, which can possibly influence these differences. Therefore, this study provided an additional piece of evidence towards the existence of a geographic gradient of carotid IMT.

Recent reports suggest an association between ethnicity and COVID-19 mortality. In the present multi-center study, we aimed to assess the differences underlying this association, and ascertain whether ethnicity also mediates other aspects of COVID-19 like cardiovascular complications.

Data were collected from a mixed-ethnicity UK cohort of 613 patients admitted and diagnosed COVID-19 positive, across six hospitals in London during the second half of March 2020 292 were White Caucasian ethnicity, 203 were Asian and 118 were of Afro-Caribbean ethnicity.

Caucasian patients were older (P<0.001) and less likely to have hypertension (P=0.038), while Afro-Caribbean patients had higher prevalence of diabetes mellitus (P<0.001). Asian patients were more likely to present with venous thromboembolic disease (adj.OR=4.10, 95% CI 1.49-11.27, P=0.006). On the other hand, Afro-Caribbean had more heart failure (adj.OR=3.64, 95% CI 1.50-8.84, P=0.004) and myocardial injury (adj.OR=2.64, 95% CI 1.10-6.35, P=0.030).mplications more likely to arise in specific ethnicities will allow a more timely diagnosis and preventive measures for patients at risk. selleck inhibitor Due to increased mortality, individuals of Afro-Caribbean and Asian ethnicity should be considered as high-risk groups. This may have an impact on health-resource allocation and planning, definition of vulnerable groups, disease management, and the protection of healthcare workers at the frontline.Most studies on leptin in diabetes mellitus (DM) compared to healthy controls were done in Caucasians, with conflicting findings. Paucity of data on this exists in Nigerian-Africans. Therefore, the study determined plasma leptin concentrations in newly diagnosed type-2 diabetes versus controls and its relation to obesity/demographic-metabolic indices. A cross-sectional comparative study on 154 subjects 67 diabetes and 87 healthy controls at the Ahmadu Bello University Teaching Hospital, Nigeria. Leptin was determined by the sandwich enzyme-linked immunosorbent assay. Mann-Whitney U test, Spearman’s Correlation and Step-wise Multiple Logistic Regression analysis of Log-transformed variables determined outcomes. Leptin trended towards lower levels in DM subjects than controls when both sexes were combined, though insignificant (P=0.12). Leptin was significantly (P0.05) correlation to fasting insulin (FI) and HOMA-IR. WC was an independent predictor of Ln10hyperleptinaemia in DM subjects (OR 1.12, 95% CI, 1.03-1.23, P=0.01). BMI showed significant (P less then 0.001) association with Ln10hyperleptinaemia in both subjects. Conclusively, leptin trends towards lower levels but are not different in newly diagnosed DM than controls. The association of leptin with obesity is similar but stronger in diabetes than controls, with no relations to FI and HOMA-IR. WC and BMI are independent predictors of hyperleptinaemia.

Venous thromboembolism (VTE) is a well-established complication of trauma. So far, the factors that are related to early post-traumatic pulmonary embolism (PE) occurrence have been given little attention.

We have conducted this literature review in order to analyze the incidence and the physiopathology of post-traumatic PE among intensive care unit (ICU) trauma patients, analyze the incidence of early post-traumatic PE, and elucidate risk factors associated with post-traumatic PE. Moreover, we aim to study the impact/outcome of post-traumatic PE in the ICU.

We used the PubMed and EMBASE databases and entered the following key words in MeSH research Deep vein thrombosis (DVT), Post-traumatic Pulmonary embolism, Early pulmonary-embolism, risk factors, and Prognosis.

The incidence of PE among trauma patients varies considerably, ranging from 0.35% to 24%. The incidence of early post-traumatic PE varies widely from 10 to 42%. After a traumatic injury, many factors have been found to be responsible for the formation of DVT and PE.