Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder that results from a deficiency of α-galactosidase A enzyme activity in which glycosphingolipids gradually accumulate in multi-organ systems. Paclitaxel Cardiac manifestations are the leading cause of mortality in patients with AFD. Among them, arrhythmias comprise a large…[Read more]

This article is part of the theme issue ‘Challenging the paradigm in sex chromosome evolution empirical and theoretical insights with a focus on vertebrates (Part I)’.So far, very few sex-determining genes have been identified in vertebrates and most of them, the so-called ‘usual suspects’, evolved from genes which fulfil essential functions…[Read more]

After recoating, motorists also kept a greater distance from the cycle lane; a greater share of cyclists chose to cycle in the cycle lane and a lower share cycled on the pavement. Analysis of survey data showed that visibility, perceived safety and ease of visualisation improved more in the recoated streets than in control streets. Analysis of the…[Read more]