2 μg mL-1) whereas ethyl acetate fraction was highly effective against Sclerotinia sclerotiorum (112.1 μg mL-1). Selleck Epigenetic inhibitor Comparative assessment of C. globosum 5157 vis a vis Trichoderma harzianum A28 revealed promising effect of C. globosum 5157 with respect to antifungal properties and plant growth promotion of Brassica seedlings.

The American Association of Hip and Knee Surgeons (AAHKS) has one of the lowest percentages of women members among orthopedic surgery subspecialty societies, having increased from 1.3% to 3.1% since 2012. Our purpose was to report the representation of women in various speaking roles at the AAHKS annual meeting over this time period.

We accessed the 2012-2019 AAHKS annual meeting programs online and reviewed all paper presenters, symposium faculty, and session moderators. We recorded instances of women speakers and their degree and specialty. We calculated the percentage of women speakers, women orthopedic surgeon speakers, women session moderators, and women symposium faculty for the overall period of 2012-2019, and for each annual meeting.

Between 2012 and 2019, 33/877 (3.8%) of all speakers at AAHKS were women. Of these, 21 were women orthopedic surgeons, or 2.4% of all speakers. The proportion of total women speakers per year ranged from 1.7% (2017) to 6.4% (2013). Twenty-four of 492 (4.9%) paper presenters were women, and 12/492(2.4%) were women orthopedic surgeons. Four of 143 (2.8%) session moderators were women, and all were orthopedic surgeons. Five of 245 (2.0%) symposium faculty were women, and 0/245 (0%) were women orthopedic surgeons.

Although the percentage of women AAHKS members has grown since 2012, the small percentage of women orthopedic surgeons speaking at AAHKS has not. There were no women orthopedic surgeons included on symposium faculty over this entire period. We appreciate and encourage efforts to improve gender diversity among speakers at AAHKS annual meetings.

Although the percentage of women AAHKS members has grown since 2012, the small percentage of women orthopedic surgeons speaking at AAHKS has not. There were no women orthopedic surgeons included on symposium faculty over this entire period. We appreciate and encourage efforts to improve gender diversity among speakers at AAHKS annual meetings.

Contemporary total hip arthroplasty (THA) employs larger femoral heads to optimize hip stability. However, the combination of large femoral heads and comparatively small acetabular components poses a potential risk for implant failure secondary to polyethylene (PE) liner fracture or dissociation. The purpose of this study was to evaluate the incidence of liner fracture or dissociation, implant survivorship, and PE wear rates in primary THAs using large femoral heads and small acetabular components.

Between 2000 and 2017, we retrospectively identified 882 primary THAs with 36 mm femoral heads and acetabular components ≤52 mm with highly cross-linked polyethylene liners. Mean age was 66 years, 88% were females, and mean body mass index was 30 kg/m

. We evaluated the cumulative incidences of dislocation, any revision, and any reoperation utilizing a competing risk model. Osteolysis and femoral head penetration were assessed with a validated radiographic technique at minimum 10-year follow-up (n= 18). Mean follow-up was 4 years.

There were no liner fractures or dissociations in the entire cohort. The 10-year cumulative incidences of dislocation, any revision, and any reoperation were 3.2%, 5.6%, and 9.3%, respectively. Mean linear femoral head penetration was 0.042 mm/y and mean volumetric wear rate was 44 mm

/y. No THAs demonstrated evidence of osteolysis or component loosening at long-term follow-up.

In a large cohort of primary THAs pairing large femoral heads with small acetabular components, there was no evidence of liner fracture or dissociation. Cumulative incidences of dislocation, any revision, and any reoperation were low at mid-term.

IV.

IV.

To assess clinical outcomes according to the immunosuppressive treatment administered to patients with severe SARS-CoV-2 pneumonia and moderate inflammation.

A retrospective observational cohort study involving 142 patients with severe COVID-19 pneumonia and moderate inflammation divided into three treatment groups (pulses of methylprednisolone alone [groupI], tocilizumab alone [groupII] and methylprednisolone plus tocilizumab [groupIII]). The aim was to assess intergroups differences in the clinical course with a 60-day follow-up and related analytical factors.

14 patients (9,8%) died 8 (10%) in groupI and 6 (9,5%) in groupsII andIII. 15 (10,6%) were admitted to ICU 2 (2,5%) from groupI, 4 (28,5%) from groupII and 9 (18,4%) from groupIII. The mean hospital stay was longer in groupII and clinical outcome was not associated with treatment.

Tocilizumab seems to be not associated with better clinical outcomes and should be reserved for clinical trial scenario, since its widespread use may result in higher rate of ICU admission and longer mean hospital stay without differences in mortality rate and potentially adverse events.

Tocilizumab seems to be not associated with better clinical outcomes and should be reserved for clinical trial scenario, since its widespread use may result in higher rate of ICU admission and longer mean hospital stay without differences in mortality rate and potentially adverse events.

Liberal oxygen therapy might increase the mortality rate of patients. Non-rebreathing masks (NRM) are a high-flow, non-invasive oxygen device that can provide oxygen concentration up to 95%. This study aimed to determine the impact of using NRM in patients with respiratory failure.

This retrospective cohort study was conducted in four medical institutions in Taiwan from January 2010 to December 2016. The association between mortality and NRM use before receiving ventilator support in patients with respiratory failure in the emergency department was analyzed. Patients were divided into the NRM treatment and no NRM treatment groups. A 14 propensity score matching was conducted. Regarding the duration of NRM use, treatments were grouped as 0h, 0-1h, 1-2h, and >2h.

A total of 18,749 patients were included, with 1074 using NRM. After propensity score matching, 1028 patients using NRM (0-1h 508, 1-2h 193, and >2h 327) and 4112 patients not using NRM were analyzed. The 30-day mortality rates were 29.1%, 28.