OBJECTIVE To investigate current Down syndrome live birth and death rates, and childhood hospitalisations, compared with peers. SETTING General community. PARTICIPANTS All live births with Down syndrome, 1990-2015, identified via Scottish regional cytogenetic laboratories, each age-sex-neighbourhood deprivation matched with five non-Down syndrome…[Read more]

IsomiRs, especially the dominant isomiRs with shifted seeds, may disturb the coding-non-coding RNA regulatory network. These findings provide insight into the multiple isomiRs and isomiR-mediated control of gene expression in the pathogenesis of cancer.Some organism-specific databases about regulation in bacteria have become larger, accelerated by…[Read more]