73 to -3.15, P < 0.00001) for SDS score, pramipexole therapy also decreased SAS score markedly (P < 0.0001). Compared with control group, the pooled effects of pramipexole on motor UPDRS score and activities of daily living UPDRS score were statistically significant (P < 0.01). Furthermore, pramipexole therapy didn’t increase the number of any adverse events in dPD patients (RR 0.72, 95 % CI 0.37-1.41, P = 0.34).

Pramipexole therapy can alleviate depressive symptoms and motor dysfunction in dPD patients, and there were no more side effects associated with drug intervention. Mitochondrial Metabolism chemical These findings should be further validated by high-quality and well-designed RCTs.

Pramipexole therapy can alleviate depressive symptoms and motor dysfunction in dPD patients, and there were no more side effects associated with drug intervention. These findings should be further validated by high-quality and well-designed RCTs.Fluid-fluid interfacial adsorption has been demonstrated to be an important retention process for per and polyfluoroalkyl substances (PFAS) in porous media with air or non-aqueous phase liquids (NAPLs) present. The objective of this study was to characterize the influence of PFAS molecular structure on air-water interfacial adsorption in electrolyte solutions. Measured and literature-reported surface-tension data sets were aggregated to generate the largest compilation of interfacial adsorption coefficients measured in aqueous solutions comprising environmentally representative ionic strengths. The surface activities and interfacial adsorption coefficients (Ki) exhibited chain length trends, with greater surface activities and larger Ki values corresponding to longer chain length. The impact of multiple-component PFAS solutions on the surface activity of a select PFAS was a function of the respective surface activities and concentrations. Quantitative structure-property relationship analysis (QSPR) employing a single molecular descriptor (molar volume) was used successfully to characterize the impact of PFAS molecular structure on air-water interfacial adsorption. A previously reported QSPR model based on PFAS data generated for deionized-water solutions was updated to include more than 60 different PFAS, comprising all head-group types and a wide variety of tail structures. The QSPR model developed for PFAS in electrolyte solution compared favorably to the model developed for deionized water. Additionally, the magnitude of ionic strength for non-zero ionic strength systems was determined to have relatively minimal impact on interfacial adsorption coefficients. The new QSPR model is therefore anticipated to be representative for a wide variety of PFAS and for a wide range of ionic compositions.Heavy metals and organic pollutants could pose long-term threats to the ecosystem and human health, so it is urgent for us to find a friendly and efficient material to remove pollutants in environment. Since tourmaline is widely distributed in natural environment and has many excellent physical and chemical properties including radiating far infrared energy, permanently releasing negative ions, producing an electrostatic field, releasing rare microelements, and stimulating the growth and metabolism of microorganisms and plants, tourmaline had been conducted to alleviate environmental pollution. This review summarizes the application of tourmaline in aqueous solutions and soil polluted by heavy metals and organic pollutants, the factors that affect the removal of pollutants by tourmaline and the removal mechanisms. In addition, to ensure the safe use of tourmaline, this review also elaborates the environment risks of tourmaline through its toxicity indexes to soil and plant.As the ozone hole in the North and South poles continues to increase, the entire ecosystem will face an environmental crisis caused by enhanced UV-B radiation. Considering the function of TiO2 and the application of nanomaterials in agriculture, the effect of TiO2-NPs on UV-B stress tolerance in Arabidopsis was investigated. The phenotype of plants was determined, and the expression patterns of antioxidant systems and related genes were analyzed. Modification of the antioxidant system and changes in the flavonoid content of plants were observed by histochemical staining. The effects of TiO2-NPs and UV-B on mitosis were observed at the cellular level, and the degree of DNA damage was analyzed by the detection of CPDs content. The effects of TiO2-NPs and UV-B on SOD isozymes were detected by SOD isozyme Native-PAGE electrophoresis. A laser confocal microscope was used to explore the protective mechanism of TiO2-NPs against UV-B radiation. Results showed that pretreatment of TiO2-NPs significantly alleviated the stress of UV-B radiation on plants. TiO2-NPs activated the antioxidant system of plants, improved the activity of antioxidant enzymes, and promoted the synthesis of flavonoids. Moreover, TiO2-NPs could effectively shield UV-B radiation to prevent the depolymerization of microtubules in plant cells. 10 mg/L of TiO2-NPs is a safe and effective application dose, which has no biological toxicity to plants. Our research results reported for the first time that pretreatment of TiO2-NPs could effectively alleviate UV-B stress to plants, providing new ideas for the application of nanomaterials in agriculture.The increase in global population size over the past 100 decades has doubled the requirements for energy resources. To mitigate the limited fossil fuel available, new clean energy sources being environmental sustainable for replacement of traditional energy sources are explored to supplement the current scarcity. Biomass containing lignin and cellulose is the main raw material to replace fossil energy given its abundance and lower emission of greenhouse gases and NOx when transformed into energy. Bacteria, fungi and algae decompose lignocellulose leading to generation of hydrogen, methane, bioethanol and biodiesel being the clean energy used for heating, power generation and the automobile industry. Microbial Fuel Cell (MFC) uses microorganisms to decompose biomass in wastewater to generate electricity and remove heavy metals in wastewater. Biomass contains cellulose, hemicellulose, lignin and other biomacromolecules which need hydrolyzation for conversion into small molecules by corresponding enzymes in order to be utilized by microorganisms.