Introduction During pregnancy, maternal cortisol levels are increased 3-fold by the third trimester. The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD, isoforms 1 and 2) regulates the balance between cortisol and cortisone levels. Perfluoroalkyl substances (PFAS) have been reported to inhibit 11β-HSD1 and more potently 11β-HSD2, which could lea…[Read more]

Although costs were higher by $28 million, the incremental cost-effectiveness ratio was $86,458, below the willingness-to-pay threshold. CONCLUSIONS For children at intermediate risk of SCD and HCM, in-home AED is cost effective, resulting in fewer deaths and increased QALYS for a cost below the willingness-to-pay threshold. These findings…[Read more]