Phenylketonuria (PKU) is an autosomal recessive hereditary disease and a common disorder of amino acid metabolism. The average incidence of PKU in China is approximately 1/11 000. It is characterized by lower incidence in the South and higher incidence in the North, particularly the Northwest. PKU is a treatable disease and has been listed in the national newborn screening program. Neonates with positive indication of screening can achieve satisfactory therapeutic effect by timely control of phenylalanine intake after the definite diagnosis. This guideline aims to summarize the knowledge of medical genetics and key points of clinical management of PKU, so as to improve the diagnostic level and standardize newborn screening and clinical treatment of patients.The development of clinical practice guidelines for medical genetics and genomics specialty is a key step in translating basic and clinical genetic research into evidence-based and precision clinical services. This paper briefly expounds the principles of writing high-quality and trustworthy clinical practice guidelines. According to these principles, the management framework, writing process, review and revision procedures, and application monitoring of medical genetic specialty guidelines are described. Systematic review of relevant literature for evidence applicable to the screening, diagnosis, counseling, treatment and prevention of specific genetic diseases is summarized. Specific requirements for writing and reviewing high-quality professional guidelines for medical genetics are introduced. These principles and requirements can ensure that the evidence-based methods and recommendations in the written guidelines conform to current international standards and have specific clinical purposes, scope of practice and time-tracking mechanism. Implementation of such guidelines can promote the translation of basic and clinical genetic research, promote cooperation of medical genetics and other clinical specialties and coordination of interdisciplinary clinical practice guidelines, and provide effective and safe clinical services for patients and their families.Counterpart cooperation is a major innovative measure in China’s strategy for revitalizing north-eastern China. While promoting economic progress, regional counterpart cooperation should also focus on low-carbon economy and sustainable development. Under the background of China’s proposed innovative cooperation strategy, using a multi-regional input-output (MRIO) model and structural decomposition analysis (SDA), this study takes Jilin province and its counterpart Zhejiang province as an example and decomposes the change in carbon emission intensity (CEI), which is a widely used indicator to measure regional carbon emission performance. The decomposition spans the years 2007 to 2012, at the level of two provinces and departments. By comparing the factors that drive and inhibit CEI in the two provinces, it was found that the production technology effect in Jilin province primarily drove the growth in CEI, while in Zhejiang province, the opposite occurred. Second, the structural effects of agriculture and heavy industry in Jilin province accounted for the largest proportion of this change, and the pulling effect on the increase in CEI in Jilin was significantly higher than that in Zhejiang province. Third, the scale effect of agricultural demand in Zhejiang province was much higher than that in Jilin province, and the same trend was observed for the scale effect of heavy industrial exports.Leakage of CO2 from the geological storage is a serious issue for the sustainability of the receiving fresh soil-water systems. Subsurface water quality issues are no longer related to one type of pollution in many regions around the globe. Thus, an effort has been made to review studies performed to investigate supercritical CO2 (scCO2) and CO2 enrich brine migration and it’s leakage from geological storage formations. Further, the study also reviewed it’s impacts on fresh soil-water systems, soil microbes, and vegetation. The first part of the study discussed scCO2/CO2 enrich brine migration and its leakage from storage formations along with it’s impact on pore dynamics of hydrological regimes. Later, a state-of-the-art literature survey has been performed to understand the role of CO2-brine leakage on groundwater dynamics and its quality along with soil microbes and plants. It is observed in the literature survey that most of the studies on CO2-brine migration in storage formations reported significant CO2-brine leakage due to over-pressurization through wells (injections and abandoned), fracture, and faults during CO2 injection. FR 180204 Thus, changes in the groundwater flow and water table dynamics can be the first impact of the CO2-brine leakage. Subsequently, three major alterations may also occur-(i) drop in pH of subsurface water, (ii) enhancement of organic compounds, and (iii) mobilization of metals and metalloids. Geochemical alteration depends on the amount of CO2 leaked and interactions with host rocks. Therefore, such alteration may significantly affect soil microbial dynamics and vegetation in and around CO2 leakage sites. In-depth analysis of the available literature fortifies that a proper subsurface characterization along with the bio-geochemical analysis is extremely important and should be mandatory to predict the more accurate risk of CO2 capture and storage activities on soil-water systems.Phosphorus removal from wastewater has become urgent because of eutrophication control. Phosphate concentration in control for phosphate removal and recovery by Mg-Fe oxide has been investigated. The results show that the adsorption capacity of phosphate by Mg-Fe oxide calcined at 450 °C was 28.3 mg/g, and it was kept at wide optimal adsorption pH ranges (4-10). The coexisting ions had influenced phosphate adsorption process and the order is CO32- > SO42- > NO3- > Cl-, with the inhibition rate of CO32- being 43%. Interestingly, phosphate concentration plays an important role in phosphate removal by Mg-Fe oxide. Under higher initial phosphate concentrations (200-800 mg/L), Sips model was well fitted. In addition, the adsorption kinetics was well described by the pseudo-second-order kinetic model before 25 min and the pseudo-first-order kinetic model after 25 min. In contrast, Langmuir model and pseudo-second-order kinetic model were fitted under lower initial phosphate concentrations (20-200 mg/L). The results of XRD, XPS, SEM, and TEM characterization show that Mg3(PO4)2 was formed by surface precipitation under 800 mg/L phosphate solution, and Mg-Fe layered structure was present via the unique memory effect under 20 mg/L phosphate solution.