Human exome sequences contain 15,000-20,000 variants but many variants have unknown clinical impact. In silico predictive classifiers are recognized by the American College of Medical Genetics as a resource for interpreting these “variants of uncertain significance.” Many in silico classifiers have been developed, of which PolyPhen-2 is highly…[Read more]

05), KFhe, and KFhf conditions (p less then 0.01), the T2 increase values were significantly greater under the KFhf than the HEke condition (p less then 0.05). The semitendinosus showed a significantly greater T2 increase value than other muscles under both KFhe and KFhf conditions (p less then 0.05). Performance of hip extension and knee flexion…[Read more]

However, these drugs exert their effects via various mechanisms and are associated with adverse reactions. The purpose of this review is to provide current comprehensive perspectives on the mechanisms of action, efficacy, and adverse reactions associated with the drugs most commonly used for the treatment of BPH.Traditional Chinese medicine is one…[Read more]

BACKGROUND The Certificate of Visual Impairment (CVI) provides essential data for preventable sight loss indicators as part of the Public Health Outcomes Framework (PHOF) published annually by the Department of Health. Trends in CVI certification rates can provide information on the effectiveness of current services and treatments and may be used…[Read more]

Introduction  Patients with acute pulmonary embolism (PE) are at risk of developing chronic complications including the post-PE syndrome with reduced cardiopulmonary function and chronic thromboembolism pulmonary hypertension (CTEPH). Risk stratification at PE diagnosis is an important tool in predicting early mortality; however, its use in p…[Read more]

Introduction  Patients with acute pulmonary embolism (PE) are at risk of developing chronic complications including the post-PE syndrome with reduced cardiopulmonary function and chronic thromboembolism pulmonary hypertension (CTEPH). Risk stratification at PE diagnosis is an important tool in predicting early mortality; however, its use in p…[Read more]