In contrast, while cyclin E1 can localise to the preRC, its downregulation does not prevent rereplication, and overexpression promotes polyploidy via mitotic slippage. Thus, in breast cancer, cyclin E2 has a strong association with genome doubling, and likely contributes to highly proliferative and genomically unstable breast cancers.In recent…[Read more]

Elimination of septal cholinergic neurons by 192IgG-saporin abolished LTP development in both experimental series. This suppression of LTP in animals with cholinergic deficit was not due to loss of hippocampal neurons.

Our data suggest that activation of septal cholinergic fibers during tetanization is a critical factor of LTP induction in…[Read more]

Osteoporosis is a disease prevalent in older adults, characterized by high porosity in bone and subsequent decrease in fracture resistance. This demographic is also the population that most frequently receives devices such as hip implants. However, high porosity complicates surgery and reduces the fixation and effectiveness of orthopaedic devices,…[Read more]