A new metal-organic framework (MOF) with both coordination linkages and covalent linkages is prepared by coordinating CuI with pyrazolate for an aldehyde-functionalized trinuclear complex, and subsequent imine condensation with p-phenylenediamine, a reaction typical for covalent organic framework (COF) synthesis. This MOF×COF collaboration yields…[Read more]

In conclusion, our study proves that the upregulated expression of GLT25D2 decreased autophagy contributing to APAP-induced hepatotoxicity by mediating the inflammatory immune regulatory mechanism.The incidence of gastrointestinal disorders (GID) and cancers is escalating all over the world. Limited consumption of colostrum by newborns not only…[Read more]

To estimate the effect of empathy interventions in health education and training from randomised controlled trials (RCTs).

MEDLINE, PsycINFO, EMBASE, CINAHL and Cochrane databases were searched from inception to June 2019 for RCTs investigating the effect of empathy-enhancing interventions in medical and healthcare students and…[Read more]

The concept of dielectric-laser acceleration (DLA) provides the highest gradients among breakdown-limited (nonplasma) particle accelerators and thus the potential of miniaturization. The implementation of a fully scalable electron accelerator on a microchip by two-dimensional alternating phase focusing (APF), which relies on homogeneous laser…[Read more]

The research of the microbial environment and human microbiome may provide a new target for the prevention of asthma in children who have high-risk factors to allergy. However, further study of “when and how” to regulate microbiome is still needed.

We examined the agreement between peak oxygen uptake (V˙o2peak), estimated using prediction…[Read more]

Survival in LC-COPD patients greater area of TLSs and proportion of B cells were associated with longer survival rates. The immune tumor microenvironment differs in patients with underlying COPD and these different phenotypes may eventually impact the response to immunotherapy in patients with LC.The outbreak of coronavirus disease 2019…[Read more]

Acute appendicitis is the most common abdominal urgency around the world. Recent studies have investigated the efficacy of platelet distribution width (PDW) in the diagnosis of acute appendicitis.

To determine if there is a correlation between PDW and the diagnosis of patients with acute appendicitis and to define their relation to the…[Read more]

Since macropinocytosis acts as an amino acid supply route, these results suggest that LY6D-mediated macropinocytosis contributes to senescent cell survival through the incorporation of extracellular nutrients.Large cytosolic protein aggregates are removed by two main cellular processes, autophagy and the ubiquitin-proteasome system (UPS), and…[Read more]