A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently infected cells with latency reversal agents (LRAs) followed by their subsequent clearance. In a screen for novel LRAs, we used fungal secondary metabolites as a source of bioactive molecules. Using orthogonal mass spectrometry (MS)…[Read more]

Bone metastasis of prostate cancer is associated with pain and reduced overall survival (OS). Radium-223, which is expected to reduce bone pain and prolong OS, was recently approved in Japan.

The aim of this study was to investigate the usefulness of the bone scan index by comparing the outcomes and factors according to response in…[Read more]

human viral pathogens (e.g., HPyV) and viral concentration methods influence the interpretation of fecal viral indicator detection.Maximizing water recovery and minimizing the volume of RO concentrate (i.e., brine) produced is a growing challenge, especially for inland communities that lack ocean disposal options. In such regions, transitioning…[Read more]

Since many offenders would presumably be committing less serious crimes in a non-pandemic world, we raise attention to the possibility that mandatory lockdown orders may have taken minor offenders and placed them into situations where there is rampant opportunity for intimate partner violence, serious batteries, and homicides. While crime in the…[Read more]

This study was conducted to examine the effect of freezing in the tea preparation using Camellia sinensis leaves in order to develop new technology for improving tea quality. Effects of single and combined treatments of freezing (F - 20 °C, 15 days), steaming (S 100 °C, 3 min), and hot-air drying (HD 50 °C, 12 h) on the physicochemical char…[Read more]

Calcifying fibrous pseudotumor, a benign spindle cell tumor, has not been reported previously in the pancreas. Herein, we report a case of pancreatic calcifying fibrous pseudotumor in a 74-year-old female with a history of metastatic breast carcinoma and gastric gastrointestinal stromal tumor (GIST), both confounding the diagnosis and rendering it…[Read more]

Age-associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice (Sod1-/- mice) recapitulates sarcopenia phenotypes, including elevated oxidative stress and accelerated muscle atrophy, weakness, and disruption of neuromuscular junctions…[Read more]

Age-associated loss of muscle mass and function (sarcopenia) has a profound effect on the quality of life in the elderly. Our previous studies show that CuZnSOD deletion in mice (Sod1-/- mice) recapitulates sarcopenia phenotypes, including elevated oxidative stress and accelerated muscle atrophy, weakness, and disruption of neuromuscular junctions…[Read more]

A 78 year-old female presented with dropped head syndrome (DHS). Three months before her initial visit to our hospital, the patient noticed a pronounced flexion of her head and neck with subsequent deterioration of symptoms, which included neck pain, difficulty with forward gaze, and gait disturbance. Cervical radiographs demonstrated scoliotic…[Read more]

Then we looked for associations between individual scores of different EF components and the whole-brain resting-state FC of the DLPFC. RESULTS Resting-state correlates of DLPFC FC were revealed for three out of the seven EF components derived from an extensive neuropsychological assessment inhibition, switching, and the verbal EF component.…[Read more]