A higher concentration of ═O and a lower concentration of -F were achieved on the TiVC synthesized by LiF/HCl, both of which provide a more favorable surface chemistry for energy-storage applications. Our results provide the first systematic study on the effect of synthesis conditions on the surface chemistry of solid-solution TiVC MXenes.Herein, we have reported on the efficiency of inorganic Zn3N2 nanoparticles for labeling plant cells and animal cells toward imaging applications with negligible toxicity. We have synthesized zinc nitride (Zn3N2) colloidal nanoparticles with an average size of 25 nm at room temperature. The optical band gap of the prepared Zn3N2 nanoparticles is 2.8 eV and gives a visible range emission at 415 nm. With the addition of Zn3N2 colloids to organic dyes such as protoporphyrin, flavin adenine dinucleotide, fluorescein, and neutral red, the emission intensity of the organic dyes enhanced from 3 to 20 times. The molecular simulation and lifetime studies evidence the possibility of energy transfer from zinc nitride to organic dyes. The enhancement of dye intensity in the presence of Zn3N2 enhanced the vicinity of the cellular environment during confocal imaging of plant cells and animal cells. The detailed results suggested Zn3N2 for bioimaging and biosensor applications.BACKGROUND Pulmonary vein isolation has become one of core modalities of rhythm control strategy in patients with atrial fibrillation (AF). AIMS The aim of the study was to analyse temporal trends in availability and efficacy of AF/atrial flutter catheter (AFl) ablation in urban area of Upper Silesia in Poland. METHODS The source data was obtained from SILCARD database covering an adult population of 3.8 million. The final study population comprised patients referred for catheter ablation with I48 diagnosis code between 2006 and 2017. The data included total number of procedures, patients’ sex, age, comorbidities, number of hospital admissions, and mortality rate. RESULTS The total number of 2745 patients were enrolled. Number of patients ablated increased > 10-fold (43 in 2006 vs.507 in 2017, P = 0.008) in the observation period. The analysis showed an upward trend in female representation (P = 0.02), hypertension prevalence (P = 0.004), percentage of patients implanted (P = 0.02) and a decrease in percentage of patients with stable angina (P less then 0.005), and hospitalization length (P less then 0.005). All-cause hospital readmissions rate decreased from 55.8% to 25.4% (P less then 0.005). Significant reductions of 12-month all-cause mortality (2.3% in 2006 vs 0.2% in 2017, P less then 0.005), stroke (2.3% in 2006 vs 0.2% in 2017, P = 0.047) and myocardial infarction rates (2.3% in 2006 vs 0.4% in 2017, P = 0.03) were reported. CONCLUSIONS Over the 12-year follow-up a considerable increase in the availability and efficacy of AF / AFl ablations was documented.Herein, we unfolded miR-98-5p mechanism in inflammatory bowel disease (IBD). IBD mouse model was established. The severity of colitis was assessed daily using the disease activity index (DAI). Murine peritoneal macrophages were stimulated by lipopolysaccharide (LPS). MiR-98-5p, tribbles homolog 1 (Trib1), M1 and M2 macrophage marker genes mRNA expression was analyzed. The relationship between miR-98-5p and Trib1 was explored using a luciferase reporter assay. The strategy of loss-of-function was used to explore the mechanism of miR-98-5p in macrophage polarization, inflammation and IBD. The results revealed that IBD mice had higher DAI index and miR-98-5p expression when compared to the Sham group. MiR-98-5p and Trib1 displayed a targeted regulation relationship. find more Knockdown of miR-98-5p transformed LPS-induced M1 macrophage polarization into M2 macrophage polarization and inhibited inflammation via up-regulating Trib1. However, shTrib1 reversed the effects. In vivo experiment, silencing of miR-98-5p, diminished the DAI and promoted M2 macrophage polarization. In conclusion, knockdown of miR-98-5p changed macrophage polarization to the M2 phenotype by increasing Trib1 expression, thereby alleviating IBD symptoms.The management of dilated cardiomyopathy (DCM) is well established. However, a subset of patients does not have recovery from or have recurrences of left ventricular (LV) dysfunction despite receiving optimal medical therapy. Coronary microvascular dysfunction (CMD) can result from structural and functional abnormalities at the intramural and small coronary vessel level affecting coronary blood flow autoregulation and consequently leading to impaired coronary flow reserve. Dilated myocardial phenotype may be responsible for CMD in DCM. Anisodamine can exert a significant effect on relieving microvascular spasm, and improving and dredging the coronary microcirculation. However, whether CMD can be potentially improved with anisodamine to make DCM better remains incompletely understood.OBJECTIVE Myopia is the most common eye problem and affects an estimated 28.3% of the global population. Its incidence is increasing annually. Myopia treatment is limited to correcting visual acuity. Acupuncture is one of the main therapies in traditional Chinese medicine and includes plum-blossom needling, which has been widely used for both the prevention and treatment of adolescent myopia. We hypothesized that plum-blossom needling would be effective in treating myopia compared with a tropicamide eye drops control. METHODS This is a crossover randomized controlled trial involving adolescents with myopia. Participants will be randomized 1∶1 to plum-blossom needle or tropicamide eye drops arms. Subjects in each arm will be treated for 20 d, followed by a 1-month washout period and treatment change for another 20 d. The primary outcome is uncorrected distance and cycloplegic refractive errors. The secondary outcomes comprise corneal curvature, lens thickness, axial length, ciliary body thickness, accommodation amplitude, the NRA/PRA (negative/positive relative accommodation), flexible adjustment, and near point of convergence. The outcome measures will be assessed at baseline, after the first treatment course (the first month), at the end of the washout period (the second month), after the second treatment course (the third month), and at follow-up (the sixth month). DISCUSSION The results of the trial will help to provide evidence for the efficacy of plum-blossom needling for myopia in China.